Physical and chemical stability of a generic etoposide formulation as an alternative to etoposide phosphate

Hassane Sadou Yayé (1) , Lamia Hassani , Philippe-Henri Secrétan (2) , Martine Babiard , Haroun Aouati , Agnès Bellanger (3) , Patrick Tilleul , Najet Yagoubi (4) , Bernard Do (4) , Ivo Rietveld (5)

1 Service de biochimie hormonale, métabolique et génétique
2 Groupe matériaux et santé
3 Néonatalogie
4 IFR 141, EA 401, UFR de Pharmacie
5 SMS - Sciences et Méthodes Séparatives

Mots clés: Etoposide phosphate; Etoposide; Physico-chemical stability; Supersaturation; Solubility; Degradation products; Computational prediction

Domaines: Chimie analytique; Chimie théorique et/ou physique; Médicaments

Hassane Sadou Yayé, Lamia Hassani, Philippe-Henri Secrétan, Martine Babiard, Haroun Aouati, et al.. Physical and chemical stability of a generic etoposide formulation as an alternative to etoposide phosphate. Journal of Pharmaceutical and Biomedical Analysis, 2019, 178, pp.112896. ⟨10.1016/j.jpba.2019.112896⟩. ⟨hal-02356006⟩