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ALUMINIUM OXIDE NANOPARTICLES COMPROMISE SPATIAL LEARNING AND MEMORY PERFORMANCE IN RATS

Abstract : Recently, the biosafety and potential influences of nanoparticles on central nervous system have received more attention. In the present study, we assessed the effect of aluminium oxide nanoparticles (Al 2 O 3-NPs) on spatial cognition. Male Wistar rats were intravenously administered Al 2 O 3-NP suspension (20 mg/kg body weight/day) for four consecutive days, after which they were assessed. The results indicated that Al 2 O 3-NPs impaired spatial learning and memory ability. An increment in malondialdehyde levels with a concomitant decrease in superoxide dismutase activity confirmed the induction of oxidative stress in the hippocampus. Additionally, our findings showed that exposure to Al 2 O 3-NPs resulted in decreased acetylcholinesterase activity in the hippocampus. Furthermore , Al 2 O 3-NPs enhanced aluminium (Al) accumulation and disrupted mineral element homoeostasis in the hippocampus. However, they did not change the morphology of the hippocampus. Our results show a connection among oxidative stress, disruption of mineral element homoeostasis, and Al accumulation in the hippocampus, which leads to spatial memory deficit in rats treated with Al 2 O 3-NPs.
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Imen M'rad, Mustapha Jeljeli, Naima Rihane, Pascal Hilber, Mohsen Sakly, et al.. ALUMINIUM OXIDE NANOPARTICLES COMPROMISE SPATIAL LEARNING AND MEMORY PERFORMANCE IN RATS. EXCLI Journal, 2018, 17, pp.200 - 210. ⟨10.17179/excli2017-1050⟩. ⟨hal-02355843⟩

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