Abstract : Phase equilibria are considered a thing of the past since "Phase Theory" has been published by J.W. Gibbs 150 years ago. However, the richness in possibilities to control pharmaceutical formulations and on the other hand the delicate task of ensuring the stability of such formulations require a profound understanding of the phase behaviour of molecular compounds and of their interactions.
The presentation will highlight the importance of the solid state in close relationship to the liquid state in pharmaceutical applications. Examples will involve polymorphism, co-crystals, solubility, eutectics, miscibility gaps and racemic systems and their resolution.
