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Synthesis of 2-, 3-, and 4-Substituted Pyrido[2,3-b]indoles by C-N, C-O, and C-C(sp) Bond Formation

Abstract : The synthesis of 2-, 3-, and 4-substituted alpha-carbolines is described starting from the corresponding chloropyrido[2,3-b]-indoles by Buchwald-Hartwig and Sonogashira cross-coupling reactions. Regioselective Sonogashira reactions on 2,4-dichloropyrido[2,3-b]indoles are also presented as an efficient route to unsymmetrically 2,4-disubstituted alpha-carbolines.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02351724
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Submitted on : Wednesday, November 6, 2019 - 3:07:55 PM
Last modification on : Thursday, August 4, 2022 - 5:14:31 PM

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Cédric Schneider, David Goyard, David Gueyrard, Benoît Joseph, Peter Goekjian. Synthesis of 2-, 3-, and 4-Substituted Pyrido[2,3-b]indoles by C-N, C-O, and C-C(sp) Bond Formation. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2010, 2010 (34), pp.6665-6677. ⟨10.1002/ejoc.201000795⟩. ⟨hal-02351724⟩

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