Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis

C. Derambure (1) , G. Dzangue-Tchoupou (2, 3) , C. Bérard (4) , N. Vergne (5) , M. Hiron (2, 3) , M A d'Agostino (6) , P. Musette (3) , O. Vittecoq (7, 8, 3) , T. Lequerré (7, 8, 3)

1 GPMCND - Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques
2 Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes
3 PANTHER - Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices
4 LITIS - Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes
5 LMRS - Laboratoire de Mathématiques Raphaël Salem
6 Service de Rhumatologie [CHU Ambroise Paré]
7 Service de rhumatologie [CHU Rouen]
8 CIC Rouen - Centre d'Investigation Clinique [CHU Rouen]

Background: In the current context of personalized medicine, one of the major challenges in the management of rheumatoid arthritis (RA) is to identify biomarkers that predict drug responsiveness. From the European APPRAISE trial, our main objective was to identify a gene expression profile associated with responsiveness to abatacept (ABA) + methotrexate (MTX) and to understand the involvement of this signature in the pathophysiology of RA. Methods: Whole human genome microarrays (4 × 44 K) were performed from a first subset of 36 patients with RA. Data validation by quantitative reverse-transcription (qRT)-PCR was performed from a second independent subset of 32 patients with RA. Gene Ontology and WikiPathways database allowed us to highlight the specific biological mechanisms involved in predicting response to ABA/MTX.

Domains: Statistics [stat]; Applications [stat.AP]; Statistics [stat]; Methodology [stat.ME]; Life Sciences [q-bio]; Quantitative Methods [q-bio.QM]

C. Derambure, G. Dzangue-Tchoupou, C. Bérard, N. Vergne, M. Hiron, et al.. Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis. Arthritis Research and Therapy, 2017, 19 (1), ⟨10.1186/s13075-017-1319-8⟩. ⟨hal-02337207⟩