Skip to Main content Skip to Navigation
Journal articles

Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis

Abstract : Background: In the current context of personalized medicine, one of the major challenges in the management of rheumatoid arthritis (RA) is to identify biomarkers that predict drug responsiveness. From the European APPRAISE trial, our main objective was to identify a gene expression profile associated with responsiveness to abatacept (ABA) + methotrexate (MTX) and to understand the involvement of this signature in the pathophysiology of RA. Methods: Whole human genome microarrays (4 × 44 K) were performed from a first subset of 36 patients with RA. Data validation by quantitative reverse-transcription (qRT)-PCR was performed from a second independent subset of 32 patients with RA. Gene Ontology and WikiPathways database allowed us to highlight the specific biological mechanisms involved in predicting response to ABA/MTX.
Complete list of metadatas

Cited literature [47 references]  Display  Hide  Download

https://hal-normandie-univ.archives-ouvertes.fr/hal-02337207
Contributor : Nicolas Vergne <>
Submitted on : Tuesday, October 29, 2019 - 12:45:53 PM
Last modification on : Friday, October 23, 2020 - 4:42:24 PM
Long-term archiving on: : Thursday, January 30, 2020 - 6:22:29 PM

File

Aba-ArtResTher2017.pdf
Publisher files allowed on an open archive

Identifiers

Citation

C. Derambure, G. Dzangue-Tchoupou, C. Bérard, N. Vergne, M. Hiron, et al.. Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis. Arthritis Research and Therapy, BioMed Central, 2017, 19 (1), ⟨10.1186/s13075-017-1319-8⟩. ⟨hal-02337207⟩

Share

Metrics

Record views

69

Files downloads

178