Antigen array for serological diagnosis and novel allergen identification in severe equine asthma - Normandie Université Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2019

Antigen array for serological diagnosis and novel allergen identification in severe equine asthma

Résumé

Severe equine asthma (sEA), which closely resembles human asthma, is a debilitating and performance-limiting allergic respiratory disorder which affects 14% of horses in the Northern Hemisphere and is associated with increased allergen-specific immunoglobulin E (IgE) against a range of environmental proteins. A comprehensive microarray platform was developed to enable the simultaneous detection of allergen-specific equine IgE in serum against a wide range of putative allergenic proteins. The microarray revealed a plethora of novel pollen, bacteria, mould and arthropod proteins significant in the aetiology of sEA. Moreover, the analyses revealed an association between sEA-affected horses and IgE antibodies specific for proteins derived from latex, which has traditionally been ubiquitous to the horse's environment in the form of riding surfaces and race tracks. Further work is required to establish the involvement of latex proteins in sEA as a potential risk factor. This work demonstrates a novel and rapid approach to sEA diagnosis, providing a platform for tailored management and the development of allergen-specific immunotherapy.
Fichier principal
Vignette du fichier
White_2019.pdf (1.11 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02336957 , version 1 (29-10-2019)

Identifiants

Citer

Samuel J White, M. Moore-Colyer, E. Marti, D. Hannant, V. Gerber, et al.. Antigen array for serological diagnosis and novel allergen identification in severe equine asthma. Scientific Reports, 2019, 9 (1), pp.15170. ⟨10.1038/s41598-019-51820-7⟩. ⟨hal-02336957⟩
46 Consultations
94 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More