Expeditious Synthesis of the Topoisomerase I Inhibitors Isoindolo[2,1-b]isoquinolin-7(5H)-one and the Alkaloid Rosettacin Based on Aryl Radical Cyclization of Enamide Generated by Using N-Acyl­iminium Chemistry

Ata Martin Lawson (1) , Lahssen El Blidi (2) , Aurélie Namoune , Alexandre Bridoux (3) , Vijaykumar Nimbarte (1) , Ata Lawson , Sébastien Comesse (1) , Adam Daïch (1)

1 URCOM - Unité de Recherche en Chimie Organique et Macromoléculaire
2 SEESIB - Synthèse et étude de systèmes à intêret biologique
3 ICPAL - Institut de Chimie Pharmaceutique Albert Lespagnol

Domaines: Chimie; Chimie analytique; Catalyse; Chimie organique; Chimie thérapeutique

Ata Martin Lawson, Lahssen El Blidi, Aurélie Namoune, Alexandre Bridoux, Vijaykumar Nimbarte, et al.. Expeditious Synthesis of the Topoisomerase I Inhibitors Isoindolo[2,1-b]isoquinolin-7(5H)-one and the Alkaloid Rosettacin Based on Aryl Radical Cyclization of Enamide Generated by Using N-Acyl­iminium Chemistry. Synthesis: Journal of Synthetic Organic Chemistry, 2015, 47 (22), pp.3583-3592. ⟨10.1055/s-0034-1378811⟩. ⟨hal-02332633⟩