Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies

Laetitia Miguel (1, 2) , Thierry Frebourg (3, 2) , Dominique Campion (3, 2) , Magalie Lecourtois (1, 2)

1 IRIB - Institute for Research and Innovation in Biomedicine
2 GPMCND - Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques
3 Génétique médicale et fonctionnelle du cancer et des maladies neuropsychiatriques

Domains: Neurons and Cognition [q-bio.NC]

Laetitia Miguel, Thierry Frebourg, Dominique Campion, Magalie Lecourtois. Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies. Neurobiology of Disease, 2011, 41 (2), pp.398-406. ⟨10.1016/j.nbd.2010.10.007⟩. ⟨hal-02332578⟩