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Article Dans Une Revue Journal of flow chemistry Année : 2019

Continuous flow palladium-catalyzed trifluoromethylthiolation of C-H bonds

Résumé

A continuous flow process for the synthesis of trifluoromethylthioethers is reported. The palladium-catalyzed C-H trifluoromethylthiolation of amides derived from the 8-aminoquinoline using N-[(trifluoromethyl)thio]phthalimide produced the desired products in moderate to good yields with a residence time of 20 min. In comparison with the batch process, the reaction time was decreased by a factor of 100 to 200, demonstrating the positive effect of continuous flow processes for this type of reaction.

Domaines

Chimie
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Dates et versions

hal-02330475 , version 1 (24-10-2019)

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Citer

Alexanne Bouchard, Vanessa Kairouz, Maxime Manneveau, Heng-Ying Xiong, Tatiana Besset, et al.. Continuous flow palladium-catalyzed trifluoromethylthiolation of C-H bonds. Journal of flow chemistry, 2019, 9 (1), pp.9-12. ⟨10.1007/s41981-018-0023-4⟩. ⟨hal-02330475⟩
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