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Continuous flow palladium-catalyzed trifluoromethylthiolation of C-H bonds

Abstract : A continuous flow process for the synthesis of trifluoromethylthioethers is reported. The palladium-catalyzed C-H trifluoromethylthiolation of amides derived from the 8-aminoquinoline using N-[(trifluoromethyl)thio]phthalimide produced the desired products in moderate to good yields with a residence time of 20 min. In comparison with the batch process, the reaction time was decreased by a factor of 100 to 200, demonstrating the positive effect of continuous flow processes for this type of reaction.
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Contributor : Madeleine ROUX-MERLIN Connect in order to contact the contributor
Submitted on : Thursday, October 24, 2019 - 8:55:55 AM
Last modification on : Sunday, June 26, 2022 - 2:41:56 AM



Alexanne Bouchard, Vanessa Kairouz, Maxime Manneveau, Heng-Ying Xiong, Tatiana Besset, et al.. Continuous flow palladium-catalyzed trifluoromethylthiolation of C-H bonds. Journal of flow chemistry, 2019, 9 (1), pp.9-12. ⟨10.1007/s41981-018-0023-4⟩. ⟨hal-02330475⟩



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