Neuropeptide Y and α-MSH Circadian Levels in Two Populations with Low Body Weight: Anorexia Nervosa and Constitutional Thinness

Bogdan Galusca (1) , Gaëtan Prévost (2, 3) , Natacha Germain (1) , Isabelle Dubuc (2) , Yiin Ling (1) , Youssef Anouar (2) , Bruno Estour (1) , Nicolas Chartrel (2)

1 CHU de Saint-Etienne - Centre Hospitalier Universitaire de Saint-Etienne
2 DC2N - Différenciation et communication neuronale et neuroendocrine
3 Département d'Endocrinologie, Diabète et Maladies Métaboliques [CHU Rouen]

Context Anorexia nervosa (AN) presents an adaptive appetite regulating profile including high levels of ghrelin and 26RFa (orexigenic) and low levels of leptin and PYY (anorexigenic). However , this adaptive mechanism is not effective in promoting food intake. The NPY/proopiome-lanocortin (POMC) system plays a crucial role in the regulation of feeding behavior as NPY is the most potent orexigenic neuropeptide identified so far and as the POMC-derived pep-tide α-MSH drastically reduces food intake, and this peptidergic system has not been thoroughly studied in AN. Objective The aim of the present study was thus to investigate whether a dysfunction of the NPY/ POMC occurs in two populations with low body weight, AN and constitutional thinness (CT). Design and Settings This was a cross-sectional study performed in an endocrinological unit and in an academic laboratory. Investigated Subjects Three groups of age-matched young women were studied: 23 with AN (AN), 22 CT and 14 normal weight controls.

Domains: Life Sciences [q-bio]

Bogdan Galusca, Gaëtan Prévost, Natacha Germain, Isabelle Dubuc, Yiin Ling, et al.. Neuropeptide Y and α-MSH Circadian Levels in Two Populations with Low Body Weight: Anorexia Nervosa and Constitutional Thinness. PLoS ONE, 2015, 10 (3), pp.e0122040. ⟨10.1371/journal.pone.0122040⟩. ⟨hal-02330473⟩