[Long-term changes in the activity of Purkinje cells and efferent cerebellar neurons following bilateral destruction of the inferior olive].

C. Batini 1 Jean-Marie Billard 2
1 LGMNPN - Génétique moléculaire de la neurotransmission et des processus neurodégénératifs
2 COMETE - Mobilités : Vieillissement, Pathologie, Santé
Abstract : The spontaneous discharge frequency of Purkinje cells and neurones of the cerebellar nuclei was evaluated in rats after complete bilateral destruction of their inferior olive with 3-acetylpyridine, performed one day to six months before. The deafferentation from the climbing fibers produced an increased inhibitory action of the Purkinje cells on their target neurones, lasting at least for one week. A relative compensation took place progressively during the first month, but the normal activity of the circuit did not recover even after six months.
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Article dans une revue
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02325802
Contributeur : Jean-Marie Billard <>
Soumis le : mardi 22 octobre 2019 - 12:40:54
Dernière modification le : mercredi 23 octobre 2019 - 01:44:21

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  • HAL Id : hal-02325802, version 1
  • PUBMED : 6437616

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COMUE-NORMANDIE | COMETE | CNRS | UPMC | SORBONNE-UNIVERSITE | UNICAEN

Citation

C. Batini, Jean-Marie Billard. [Long-term changes in the activity of Purkinje cells and efferent cerebellar neurons following bilateral destruction of the inferior olive].. Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, Elsevier, 1984, 299 (12), pp.521-4. ⟨hal-02325802⟩

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