Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity

J Parcq; T. Bertrand; A. Montagne; A Baron; R Macrez; Jean-Marie Billard; A Briens; y Hommet; J. Wu; M yepes; H Lijnen; P Dutar; E Anglés-Cano; D. Vivien

doi:10.1038/cdd.2012.86

Journal articles

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity

J Parcq ¹ T. Bertrand ¹ A. Montagne ¹ A Baron ¹ R Macrez ¹ Jean-Marie Billard ² A Briens ¹ y Hommet ¹ J. Wu ³ M yepes ³ H Lijnen ⁴ P Dutar ² E Anglés-Cano ¹ D. Vivien ¹

1 Sérine protéases et physiopathologie de l'unité neurovasculaire

2 U894 / UMS 1266 - Institut de psychiatrie et neurosciences

3 Emory University [Atlanta, GA]

4 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Neurons and Cognition [q-bio.NC]

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https://hal-normandie-univ.archives-ouvertes.fr/hal-02325153
Contributor : Jean-Marie Billard Connect in order to contact the contributor
Submitted on : Tuesday, October 22, 2019 - 10:52:25 AM
Last modification on : Wednesday, October 27, 2021 - 4:03:29 PM

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity

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Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity

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