Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity

J Parcq (1) , T. Bertrand (1) , A. Montagne (1) , A Baron (1) , R Macrez (1) , Jean-Marie Billard (2) , A Briens (1) , Y Hommet (1) , J. Wu (3) , M Yepes (3) , H Lijnen (4) , P Dutar (2) , E Anglés-Cano (1) , D. Vivien (1)

1 Sérine protéases et physiopathologie de l'unité neurovasculaire
2 U894 / UMS 1266 - Institut de psychiatrie et neurosciences
3 Emory University [Atlanta, GA]
4 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven

Domains: Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]

J Parcq, T. Bertrand, A. Montagne, A Baron, R Macrez, et al.. Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity. Cell Death and Differentiation, 2012, 19 (12), pp.1983-1991. ⟨10.1038/cdd.2012.86⟩. ⟨hal-02325153⟩