Estimates of worldwide burden of cancer in 2008: GLOBOCAN, Int J Cancer, vol.127, pp.2893-917, 2008. ,
Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer, N Engl J Med, vol.350, pp.1945-52, 2004. ,
Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck, N Engl J Med, vol.350, pp.1937-1981, 2004. ,
Human papillomavirus and survival of patients with oropharyngeal cancer, N Engl J Med, vol.363, pp.24-35, 2010. ,
Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study, Radiother Oncol, vol.77, pp.18-24, 2005. ,
Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3, Int J Cancer, vol.125, pp.2198-204, 2009. ,
Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck, Int J Radiat Oncol Biol Phys, vol.38, pp.285-294, 1997. ,
Intratumoural level of SDF-1 correlates with survival in head and neck squamous cell carcinoma, Oral Oncol, vol.47, pp.1062-1070, 2011. ,
Involvement of SDF-1alpha/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma, Int J Cancer, vol.122, pp.91-100, 2008. ,
Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo, J Cell Biochem, vol.89, pp.462-73, 2003. ,
Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis, Oncogene, vol.25, pp.4986-97, 2006. ,
Involvement of chemokine receptors in breast cancer metastasis, Nature, vol.410, pp.50-56, 2001. ,
Emerging targets in cancer management: role of the CXCL12/CXCR4 axis, OncoTargets Ther, vol.6, pp.1347-61, 2013. ,
SDF-1alpha promotes invasion of head and neck squamous cell carcinoma by activating NF-kappaB, J Biol Chem, vol.283, pp.19888-94, 2008. ,
Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases, Eur J Cancer, vol.2011, issue.47, pp.452-461, 1990. ,
New insight into the SDF-1/CXCR4 axis in a breast carcinoma model: hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation, Mol Cancer Res, vol.10, pp.1021-1052, 2012. ,
Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1a, CAIX, LDH-5, GLUT-1, MCT1 and MCT4, BMC Cancer, vol.11, p.167, 2011. ,
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer, Int J Radiat Oncol Biol Phys, vol.51, pp.349-53, 2001. ,
Prognostic role of MMP-9 expression in head and neck carcinoma patients treated with radiotherapy or chemoradiotherapy, Oral Oncol, vol.49, pp.322-327, 2013. ,
Matrix metalloproteinase-7 and -13 expression associate to cisplatin resistance in head and neck cancer cell lines, Oral Oncol, vol.45, pp.866-71, 2009. ,
Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity -clinical relevance and prognostic value, J Cranio-Maxillo-Facial Surg, vol.33, pp.191-197, 2005. ,
Prognostic value of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma, Head Neck, vol.29, pp.341-50, 2007. ,
Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer, J Natl Cancer Inst, vol.97, pp.1272-86, 2005. ,
International union against Cancer. TNM classification of malignant tumours, 2010. ,
A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma, Proc Natl Acad Sci, vol.100, pp.9991-9997, 2003. ,
Selection bias in gene extraction on the basis of microarray gene-expression data, Proc Natl Acad Sci, vol.99, pp.6562-6568, 2002. ,
Prediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays, Oncogene, vol.27, pp.6607-6629, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00350835
Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma, Carcinogenesis, vol.33, pp.1707-1723, 2012. ,
Alterations in VHL as potential biomarkers in renal-cell carcinoma, Nat Rev Clin Oncol, vol.7, pp.277-88, 2010. ,
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma, N Engl J Med, vol.356, pp.115-139, 2007. ,
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial, Lancet, vol.370, pp.2103-2114, 2007. ,
Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia, Clin Cancer Res, vol.6, pp.357-62, 2000. ,
Tongue cancer patients have a high frequency of allelic loss at the von Hippel-Lindau gene and other loci on 3p, Cancer, vol.112, pp.527-561, 2008. ,
Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth, J Exp Med, vol.197, pp.221-253, 2003. ,
COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems, Am J Pathol, vol.176, pp.1469-83, 2010. ,
CXCL12/SDF1 expression by breast cancers is an independent prognostic marker of disease-free and overall survival, Eur J Cancer, vol.45, pp.2579-87, 2009. ,
Multiple functions of CXCL12 in a syngeneic model of breast cancer, Mol Cancer, vol.9, p.250, 2010. ,
Tumor entrained neutrophils inhibit seeding in the premetastatic lung, Cancer Cell, vol.20, pp.300-314, 2011. ,
The SLC16 gene family -structure, role and regulation in health and disease, Mol Aspects Med, vol.34, pp.337-386, 2013. ,
Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer, Cell Cycle, vol.12, pp.1371-84, 2013. ,
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme, J Exp Med, vol.208, pp.313-339, 2011. ,
The delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth, Nat Rev Cancer, vol.7, pp.327-358, 2007. ,
High DLL4 expression in tumour-associated vessels predicts for favorable radiotherapy outcome in locally advanced squamous cell head-neck cancer (HNSCC), Angiogenesis, vol.16, pp.343-51, 2013. ,
Hypoxia-inducible expression of tumor-associated carbonic anhydrases, Cancer Res, vol.60, pp.7075-83, 2000. ,
Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy, Clin Cancer Res, vol.7, pp.3399-403, 2001. ,
High stromal carbonic anhydrase IX expression is associated with nodal metastasis and decreased survival in patients with surgically-treated oral cavity squamous cell carcinoma, Oral Oncol, vol.48, pp.615-637, 2012. ,
Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: an evaluation of the DAHANCA 5 study, Radiother Oncol, vol.83, pp.383-391, 2007. ,
Carbonic anhydrase-9 expression in head and neck cancer: a meta-analysis, Eur Arch Oto-Rhino-Laryngol Off J Eur Fed Oto-Rhino-Laryngol Soc EUFOS Affil Ger Soc Oto-Rhino-Laryngol -Head Neck Surg, vol.268, pp.661-70, 2011. ,
Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma, Blood, vol.113, pp.5720-5726, 2009. ,
A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia, Blood, vol.119, pp.3917-3941, 2012. ,