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Invasive Geotrichum clavatum Fungal Infection in an Acute Myeloid Leukaemia Patient: A Case Report and Review

Vincent Camus 1 Marie-Laure Thibault 2 Marion David 3 Gilles Gargala 2 Patricia Compagnon 2 Fabien Lamoureux 2 Christophe Girault 4 Jean-Baptiste Michot 2 Aspasia Stamatoullas 1 Hélène Lanic 1 Fabrice Jardin 1 Pascal Lenain 1 Hervé Tilly 1 Stéphane Leprêtre 1
1 Service d'hématologie
2 Hôpital Charles Nicolle [Rouen]
3 CLCC Henri Becquerel - Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen
4 CHU Rouen
Abstract : Invasive Geotrichum clavatum fungal infections are extremely rare and unusual, occurring nearly exclusively in patients experiencing prolonged neutropenia during the treatment for acute myeloid leukaemia. Several groups of cases of fatal G. clavatum infection were reported in France between 2011 and 2012, but the ecological niche has not yet been identified. We report a case of a 32-year-old patient with acute myeloid leukaemia who developed G. clavatum sepsis with primary peritonitis, hepatic nodular lesions, and multivisceral failure during apla-sia after induction followed by salvage chemotherapy. He was treated with voriconazole and is still alive 1 year after with controlled disease. We then discuss the epidemiological, clinical, and therapeutic features of these serious fungal infections compared to the published data.
Keywords : Voriconazole Invasive fungal infection Acute myeloid leukaemia Geotrichum clavatum
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02317977
Contributeur : Venceslas Villier <>
Soumis le : jeudi 17 octobre 2019 - 09:50:54
Dernière modification le : samedi 19 octobre 2019 - 01:13:33

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COMUE-NORMANDIE | FNCLCC | BECQUEREL

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Vincent Camus, Marie-Laure Thibault, Marion David, Gilles Gargala, Patricia Compagnon, et al.. Invasive Geotrichum clavatum Fungal Infection in an Acute Myeloid Leukaemia Patient: A Case Report and Review. Mycopathologia, Springer Verlag, 2014, 177 (5-6), pp.319-324. ⟨10.1007/s11046-014-9746-4⟩. ⟨hal-02317977⟩

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