Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection

Jean-Paul Duong van Huyen (1) , Marion Tible (1) , Arnaud Gay (2) , Romain Guillemain (1) , Olivier Aubert (3) , Franck Iserin (4) , Philippe Rouvier (5) , Arnaud François (2, 6) , Déwi Vernerey (1) , Xavier Loyer (1) , Pascal Leprince (7) , Jean-Philippe Empana (1) , Patrick Bruneval (8, 1) , Alexandre Loupy (1) , Xavier Jouven (1)

1 PARCC - UMR-S U970 - Paris-Centre de Recherche Cardiovasculaire
2 CHU Rouen
3 HEGP - Hôpital Européen Georges Pompidou [APHP]
4 Service de cardiologie pédiatrique [CHU Necker]
5 ACP - Service d'Anatomie et cytologie pathologiques = Service de Pathologie [CHU Pitié-Salpêtrière]
6 ESCAPE - Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle
7 CHU Pitié-Salpêtrière [AP-HP]
8 Service d'anatomo-pathologie [CHU HEGP]

BACKGROUND: Antibody-mediated rejection (AMR) contributes to heart allograft loss. However, an important knowledge gap remains in terms of the pathophysiology of AMR and how detection of immune activity, injury degree, and stage could be improved by intragraft gene expression profiling.

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Cellular Biology

Jean-Paul Duong van Huyen, Marion Tible, Arnaud Gay, Romain Guillemain, Olivier Aubert, et al.. Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection. Circulation, 2017, 135 (10), pp.917-935. ⟨10.1161/CIRCULATIONAHA.116.022907⟩. ⟨hal-02317970⟩