First Description of Azole-Resistant Aspergillus fumigatus Due to TR 46 /Y121F/T289A Mutation in France

Rose-Anne Lavergne (1) , Florent Morio (2) , Loïc Favennec (3, 4, 5) , Stéphane Dominique (6) , Jacques Meis (7) , Gilles Gargala (8) , Paul E Verweij (7) , Patrice Le Pape (2)

1 Service de Parasitologie et Mycologie [CHU Toulouse]
2 CHU Nantes - Centre hospitalier universitaire de Nantes
3 Pharmacie [CHU Rouen]
4 PROTAL - Protozooses Transmises par l'Alimentation (Cryptosporidiose, Giardose et Toxoplasmose) : Mode de Contamination et Pathogénie (PROTAL) - EA 3800
5 ESCAPE - Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle
6 Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen]
7 Radboud University Medical Center [Nijmegen]
8 CHU Rouen

Azole resistance in Aspergillus fumigatus is an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51A gene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description of A. fumigatus carrying this mutation in France, in a cystic fibrosis patient, underlining the need for extensive monitoring of Aspergillus resistance.

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Mycology; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Rose-Anne Lavergne, Florent Morio, Loïc Favennec, Stéphane Dominique, Jacques Meis, et al.. First Description of Azole-Resistant Aspergillus fumigatus Due to TR 46 /Y121F/T289A Mutation in France. Antimicrobial Agents and Chemotherapy, 2015, 59 (7), pp.4331-4335. ⟨10.1128/AAC.00127-15⟩. ⟨hal-02317942⟩