First Description of Azole-Resistant Aspergillus fumigatus Due to TR 46 /Y121F/T289A Mutation in France

Abstract : Azole resistance in Aspergillus fumigatus is an emerging public health concern. Recently, a novel fungicide-driven mutation in the cyp51A gene and its promoter, TR46/Y121F/T289A, leading to high-level resistance to voriconazole has been identified in The Netherlands, Belgium, Germany, Denmark, Tanzania, and India in both clinical and environmental samples. Here we report the first description of A. fumigatus carrying this mutation in France, in a cystic fibrosis patient, underlining the need for extensive monitoring of Aspergillus resistance.
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Rose-Anne Lavergne, Florent Morio, Loïc Favennec, Stéphane Dominique, Jacques Meis, et al.. First Description of Azole-Resistant Aspergillus fumigatus Due to TR 46 /Y121F/T289A Mutation in France. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2015, 59 (7), pp.4331-4335. ⟨10.1128/AAC.00127-15⟩. ⟨hal-02317942⟩

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