Cyberlindnera jadinii (teleomorph Candida utilis) candidaemia in a patient with aplastic anaemia: a case report

Pauline Treguier (1, 2) , Marion David (3) , Gilles Gargala (4, 1, 5) , Vincent Camus (1, 2) , Aspasia Stamatoullas (2, 1) , Anne-Lise Menard (2, 1) , Pascal Lenain (2, 1) , Nathalie Contentin (2, 1) , Émilie Lemasle (2, 1) , Hélène Lanic (2, 1) , Hervé Tilly (2, 1) , Fabrice Jardin (2, 1) , Stéphane Leprêtre (2, 1)

1 GPMCND - Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques
2 Service d'hématologie
3 CLCC Henri Becquerel - Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen
4 CHU Rouen
5 ESCAPE - Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle

Introduction. We present what is believed to be the first report of candidaemia caused by Cyberlindnera (Pichia) jadinii (teleomorph of Candida utilis) in a patient with an aplastic anaemia. Case presentation. The patient, a 21-year-old male, presented with hepatic cytolysis, cutaneous and pulmonary involvement, and septic shock. Cyberlindnera jadinii was identified by aerobic blood culture and MS. The patient initially received multiple and combined antifungal therapy, but continued to have persistent skin lesions and fever. He was successfully treated by emergency haploidentical haematopoietic stem cell transplantation, combined with triple antifungal therapy and supportive care. Conclusion. Cyberlindnera jadinii, teleomorph of Candida utilis, which is not usually invasive, can lead to an opportunistic invasive infection in unhealthy adult patients. For treatment of the invasive candida infection, it is necessary to combine antifungal therapy and supportive care.

Mots clés: Cyberlindnera jadinii; medullary aplasia; candidaemia

Domaines: Maladies infectieuses; Hématologie

Pauline Treguier, Marion David, Gilles Gargala, Vincent Camus, Aspasia Stamatoullas, et al.. Cyberlindnera jadinii (teleomorph Candida utilis) candidaemia in a patient with aplastic anaemia: a case report. JMM Case reports, 2018, 5 (8), ⟨10.1099/jmmcr.0.005160⟩. ⟨hal-02316592⟩