Tacrolimus ointment in the management of atopic keratoconjunctivitis

Abstract : Introduction: Atopic keratoconjunctivitis is frequently associated with atopic eyelid dermatitis. It may require topical steroids, the prolonged use of which may cause ocular complications. Tacrolimus is an immunosuppressant used topically on the skin in atopic dermatitis. The purpose of this study is to evaluate the efficacy and tolerability of tacrolimus 0.1% ointment applied to the eyelids in atopic keratoconjunctivitis.
Patients and methods: This is a single center, retrospective study carried out between June 2014 and February 2017. Patients presenting with atopic keratoconjunctivitis uncontrolled by first-line medical treatment were included. The main outcome was change in functional symptoms as evaluated by the NEI-VFQ25 and OSDI quality of life scores. Secondary criteria were visual acuity and topical steroids use.
Results: Among the 18 patients included, the mean age was 37.9 ± 16.8 years. The first follow-up visit occurred on average 68.3 ± 55.3 days after initiation of treatment. The NEI-VFQ25 score improved significantly for seven of the sub-scores (P < 0.05), and the mean OSDI decreased significantly from 52.3 ± 26.2 to 22.0 ± 27.0 (P < 0.001), demonstrating a decrease in ocular symptoms. A significant reduction in the number of patients requiring topical steroid treatment was observed. There was no significant change in visual acuity.
Conclusion: Tacrolimus 0.1% ointment applied to the eyelids appears to be an effective treatment in the management of atopic keratoconjunctivitis.