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Tacrolimus pommade dans la prise en charge de la kératoconjonctivite atopique

Abstract : Introduction: Atopic keratoconjunctivitis is associated with eyelid eczema. It may require the use of local corticosteroids which if prolonged can be a source of ocular complications. Tacrolimus is an immunosuppressant used in cutaneous application in atopic dermatitis. The aim of this study was to measure the efficacy and tolerance of tacrolimus 0.1% ointment in palpebral application in atopic keratoconjunctivitis.
Patients and methods: This retrospective, single-center study was conducted between June 2014 and February 2017. Patients with atopic keratoconjunctivitis not controlled by first-line medical treatments were included. The primary endpoint was the evolution of functional signs as assessed by the NEI-VFQ25 and OSDI quality of life scores. Secondary endpoints were visual acuity and local corticosteroid use.
Results: Among the 18 patients included, the mean age was 37.9 ± 16.8 years. The first follow-up visit was on average 68.3 ± 55.3 days after initiation of treatment. The NEI-VFQ25 score was significantly improved for seven of its sub-scores (P < 0.05) and the mean OSDI decreased significantly from 52.3 ± 26.2 to 22.0 ± 27.0 (P < 0.001) showing a decrease in eye discomfort. A significant reduction was observed in the number of patients using local corticosteroids. There was no significant change in visual acuity.
Conclusion: Tacrolimus ointment 0.1% in palpebral application appears to be an effective treatment for the management of atopic keratoconjunctivitis.
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Submitted on : Tuesday, October 15, 2019 - 1:58:33 PM
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D. Benaim, F. Tetart, O. Bauvin, A. Delcampe, P. Joly, et al.. Tacrolimus pommade dans la prise en charge de la kératoconjonctivite atopique. Journal Français D'Ophtalmologie, Elsevier Masson, 2019, 42 (5), pp.435-440. ⟨10.1016/j.jfo.2018.07.018⟩. ⟨hal-02316561⟩



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