Light chain lambda myeloma with fatal AL cardiac amyloidosis in a 21‐year‐old patient: A case report and review

Vincent Camus (1) , Sydney Dubois (2) , Pierre‐alain Thiébaut (3) , Stéphane Leprêtre (1) , Pascal Lenain (1) , Jean‐michel Picquenot (3) , Elena‐liana Veresezan (3) , Arnaud François (3, 4) , Dominique Penther (5) , Fabrice Bauer (6) , Arnaud Jaccard (7) , Fabrice Jardin (1)

1 GPMCND - Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques
2 Service de Médecine Interne [CHU Rouen]
3 Département de Pathologie [CHU Rouen]
4 ESCAPE - Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle
5 CLCC Henri Becquerel - Département d'Oncologie Génétique [Rouen]
6 Service de Cardiologie [CHU Rouen]
7 CNR de l'amylose AL et des autres maladies par dépôt d'immunoglobulines monoclonales [CHU Limoges]

Multi-organ AL amyloidosis is a therapeutic challenge because of light chain deposits severely damaging the function of concerned organs. Cardiac involvement, which leads to concentric hypertrophy of both ventricles, is particularly severe and leads to poor prognosis regardless of combination chemotherapy. This case pinpoints the relevance of combining clinical, histological, and echocardiographic information in the management of this complex and life-threatening disease.

Mots clés: cardiac involvement; chemotherapy; daratumumab; light chain myeloma; multi‐organ amyloidosis

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie

Vincent Camus, Sydney Dubois, Pierre‐alain Thiébaut, Stéphane Leprêtre, Pascal Lenain, et al.. Light chain lambda myeloma with fatal AL cardiac amyloidosis in a 21‐year‐old patient: A case report and review. Clinical Case Reports, 2019, 7 (6), pp.1171-1177. ⟨10.1002/ccr3.2165⟩. ⟨hal-02316539⟩