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Journal articles
Impact of age at diagnosis on natural history of patients with elderly-onset ulcerative colitis: A French population-based study
Dana Duricova
1, 2
Benjamin Pariente
3
Hélène Sarter
4, 1
Mathurin Fumery
4, 1
Ariane Leroyer
5, 1
Cloé Charpentier
6, 1
Laura Armengol-Debeir
6, 1, 7, 8, 9
Laurent Peyrin-Biroulet
10
Guillaume Savoye
6, 7, 8, 9, 1
Corinne Gower-Rousseau
4, 1
Epimad Group
1
Dana Duricova 1, 2
Author
Benjamin Pariente 3
Author
Hélène Sarter 4, 1
Author
Mathurin Fumery 4, 1
Author
Ariane Leroyer 5, 1
Author
Cloé Charpentier 6, 1
Author
Laura Armengol-Debeir 6, 1, 7, 8, 9
Author
Laurent Peyrin-Biroulet 10
Author
1
Registre EPIMAD (Lille - Rouen - Amiens - France)
- CHRU Lille - Centre Hospitalier Régional Universitaire [Lille] (2, avenue Oscar Lambret - 59037 Lille Cedex - France)
- CHU Rouen (1, rue de Germont 76031 Rouen cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- CHU Amiens-Picardie (France)
2
IBD Clinical and Research Centre, ISCARE I.V.F., a.s., IBD Clinical and Research Centre, ISCARE I.V.F., a.s., Charles University, Prague (Charles University, Prague - Czech Republic)
3
CHRU Lille - Centre Hospitalier Régional Universitaire [Lille] (2, avenue Oscar Lambret - 59037 Lille Cedex - France)
4
LIRIC - Lille Inflammation Research International Center - U 995 (Faculté de médecine -
Pôle recherche-4ème étage -
Place de Verdun -
F-59045 Lille Cedex - - France)
- Institut Pasteur de Lille : U995 (1 Rue du Professeur Calmette - Lille Cedex - 59019 - France)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U995 (101, rue de Tolbiac, 75013 Paris - France)
- Université de Lille (Lille - France)
- CHRU Lille - Centre Hospitalier Régional Universitaire [Lille] : U995 (2, avenue Oscar Lambret - 59037 Lille Cedex - France)
5
Service d'Epidémiologie et de Santé Publique [Lille] (Hôpital Calmette - Rez de Jardin Aile Est 59037 Lille Cedex - France)
- CHRU Lille - Centre Hospitalier Régional Universitaire [Lille] (2, avenue Oscar Lambret - 59037 Lille Cedex - France)
6
Service d'Hépato-Gastroentérologie [CHU Rouen] (1 rue Germont 76031 Rouen - France)
- Hôpital Charles Nicolle [Rouen] (CHU de Rouen 1 rue de Germont, 76031 Rouen cedex - France)
- UNIROUEN - Université de Rouen Normandie (1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- CHU Rouen (1, rue de Germont 76031 Rouen cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
7
ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (22 bd Gambetta
76183 Rouen Cedex - France)
- UNIROUEN - Université de Rouen Normandie : U1073 (1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1073 (101, rue de Tolbiac, 75013 Paris - France)
8
IRIB - Institute for Research and Innovation in Biomedicine (22 Boulevard Gambetta
76183 Rouen Cedex - France)
- UNIROUEN - Université de Rouen Normandie : FED 4220 (1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- CNRS - Centre National de la Recherche Scientifique (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : FED 4220 (101, rue de Tolbiac, 75013 Paris - France)
9
UNIROUEN UFR Santé - UNIROUEN - UFR Santé (22 boulevard Gambetta - CS 76183 - 76183 Rouen cedex 1 - France)
- UNIROUEN - Université de Rouen Normandie (1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
10
NGERE - Nutrition-Génétique et Exposition aux Risques Environnementaux (Université de Lorraine, Faculté de Médecine, 9 avenue de la Forêt de Haye, 54500 Vandoeuvre-les-Nancy - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMRS954/UMRS1256 (101, rue de Tolbiac, 75013 Paris - France)
- UL - Université de Lorraine (34 cours Léopold - CS 25233 - 54052 Nancy cedex - France)
Abstract : Background. Recent population-based study of elderly-onset Crohn’s disease patients reported age-related differences in disease phenotype and outcome.
Aims. The aim was to assess the impact of age at diagnosis on natural history of elderly-onset ulcerative colitis patients with emphasis on disease presentation, phenotype and treatment.
Methods. Elderly-onset patients with ulcerative colitis (≥60 years at diagnosis) registered in a French population-based Registry EPIMAD (1988–2006) were included. Demographic and clinical data at diagnosis and at maximal follow-up were collected using predefined questionnaire.
Results. Four-hundred and sixty-five elderly-onset ulcerative colitis patients were included (median follow-up 6.2 years); 276 (59%) were <70 and 189 (41%) ≥70 years at diagnosis. Patients aged <70 years presented with more rectal bleeding (86% vs. 79%, p = .06) and abdominal pain (44% vs. 34%, p = .04) while those ≥70 years had higher rate of left-sided colitis (62% vs. 49%; p = .02). Cumulative exposure to 5-ASA, corticosteroids and immunosuppressants was similar between the groups as well as surgery rate. However, patients <70 years were significantly more steroid-resistant than older individuals (12% vs. 3%, p < .05) while no significant difference in steroid-dependency was observed.
Conclusion. Patients with elderly-onset ulcerative colitis differed in presentation, disease phenotype and response to medication with respect to age at diagnosis.
Aims. The aim was to assess the impact of age at diagnosis on natural history of elderly-onset ulcerative colitis patients with emphasis on disease presentation, phenotype and treatment.
Methods. Elderly-onset patients with ulcerative colitis (≥60 years at diagnosis) registered in a French population-based Registry EPIMAD (1988–2006) were included. Demographic and clinical data at diagnosis and at maximal follow-up were collected using predefined questionnaire.
Results. Four-hundred and sixty-five elderly-onset ulcerative colitis patients were included (median follow-up 6.2 years); 276 (59%) were <70 and 189 (41%) ≥70 years at diagnosis. Patients aged <70 years presented with more rectal bleeding (86% vs. 79%, p = .06) and abdominal pain (44% vs. 34%, p = .04) while those ≥70 years had higher rate of left-sided colitis (62% vs. 49%; p = .02). Cumulative exposure to 5-ASA, corticosteroids and immunosuppressants was similar between the groups as well as surgery rate. However, patients <70 years were significantly more steroid-resistant than older individuals (12% vs. 3%, p < .05) while no significant difference in steroid-dependency was observed.
Conclusion. Patients with elderly-onset ulcerative colitis differed in presentation, disease phenotype and response to medication with respect to age at diagnosis.
Document type :
Journal articles
Complete list of metadata
https://hal-normandie-univ.archives-ouvertes.fr/hal-02315994
Contributor : Sabine Douville Connect in order to contact the contributor
Submitted on : Tuesday, October 15, 2019 - 8:56:30 AM
Last modification on : Wednesday, November 3, 2021 - 6:20:16 AM
Contributor : Sabine Douville Connect in order to contact the contributor
Submitted on : Tuesday, October 15, 2019 - 8:56:30 AM
Last modification on : Wednesday, November 3, 2021 - 6:20:16 AM
Identifiers
- HAL Id : hal-02315994, version 1
- DOI : 10.1016/j.dld.2018.04.011
- PUBMED : 29739650
Collections
COMUE-NORMANDIE | UNIROUEN | ADEN | RIIP | RIIP_LILLE | UNIV-LORRAINE | UNIV-LILLE | NGERE-UL | CNRS | BMS-UL
Citation
Dana Duricova, Benjamin Pariente, Hélène Sarter, Mathurin Fumery, Ariane Leroyer, et al.. Impact of age at diagnosis on natural history of patients with elderly-onset ulcerative colitis: A French population-based study. Digestive and Liver Disease, WB Saunders, 2018, 50 (9), pp.903-909. ⟨10.1016/j.dld.2018.04.011⟩. ⟨hal-02315994⟩
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