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Impact of age at diagnosis on natural history of patients with elderly-onset ulcerative colitis: A French population-based study

Abstract : Background. Recent population-based study of elderly-onset Crohn’s disease patients reported age-related differences in disease phenotype and outcome.
Aims. The aim was to assess the impact of age at diagnosis on natural history of elderly-onset ulcerative colitis patients with emphasis on disease presentation, phenotype and treatment.
Methods. Elderly-onset patients with ulcerative colitis (≥60 years at diagnosis) registered in a French population-based Registry EPIMAD (1988–2006) were included. Demographic and clinical data at diagnosis and at maximal follow-up were collected using predefined questionnaire.
Results. Four-hundred and sixty-five elderly-onset ulcerative colitis patients were included (median follow-up 6.2 years); 276 (59%) were <70 and 189 (41%) ≥70 years at diagnosis. Patients aged <70 years presented with more rectal bleeding (86% vs. 79%, p = .06) and abdominal pain (44% vs. 34%, p = .04) while those ≥70 years had higher rate of left-sided colitis (62% vs. 49%; p = .02). Cumulative exposure to 5-ASA, corticosteroids and immunosuppressants was similar between the groups as well as surgery rate. However, patients <70 years were significantly more steroid-resistant than older individuals (12% vs. 3%, p < .05) while no significant difference in steroid-dependency was observed.
Conclusion. Patients with elderly-onset ulcerative colitis differed in presentation, disease phenotype and response to medication with respect to age at diagnosis.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02315994
Contributor : Sabine Douville <>
Submitted on : Tuesday, October 15, 2019 - 8:56:30 AM
Last modification on : Tuesday, October 13, 2020 - 10:46:50 AM

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Dana Duricova, Benjamin Pariente, Hélène Sarter, Mathurin Fumery, Ariane Leroyer, et al.. Impact of age at diagnosis on natural history of patients with elderly-onset ulcerative colitis: A French population-based study. Digestive and Liver Disease, WB Saunders, 2018, 50 (9), pp.903-909. ⟨10.1016/j.dld.2018.04.011⟩. ⟨hal-02315994⟩

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