Skip to Main content Skip to Navigation
Journal articles

Affinity kinetics of leptin-reactive immunoglobulins are associated with plasma leptin and markers of obesity and diabetes

Abstract : Obese subjects display elevated plasma levels of leptin reflecting the phenomenon of leptin resistance. Here, we aimed to determine whether leptin-reactive immunoglobulins (Ig) are present in obese and type 2 diabetes (T2D) patients and whether their plasma levels and affinity kinetics may correlate with obesity and diabetes markers. We show that leptin levels are increased in obese patients with and without T2D. Although mean plasma levels of leptin-reactive IgG were similar between study groups, IgG in obese non-diabetic patients had increased dissociation rate and lower affinity (increased dissociation equilibrium constant value; KD). In controls and diabetic patients, the association rates of leptin IgG correlated negatively with obesity and diabetes markers, respectively. In contrast, KD values correlated positively with plasma leptin levels and obesity traits in our cohort, and with diabetes markers in both the total cohort and in the obese T2D group. Taken together, our data reveal that leptin-reactive IgG are present in healthy subjects, obese, and diabetic patients but display altered affinity kinetics in obesity. Increased IgG binding to leptin in healthy subjects associated with lower body mass index (BMI) suggests an enhancing role of IgG in leptin signaling. Accordingly, a decreased affinity of IgG for leptin, found in obese patients, can be relevant to leptin resistance.
Document type :
Journal articles
Complete list of metadata

Cited literature [18 references]  Display  Hide  Download
Contributor : sabine douville Connect in order to contact the contributor
Submitted on : Tuesday, April 28, 2020 - 4:03:43 PM
Last modification on : Wednesday, April 6, 2022 - 5:04:03 PM


Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License



Houda Bouhajja, Noura Bougacha-Elleuch, Nicolas Lucas, Romain Legrand, Rim Marrakchi, et al.. Affinity kinetics of leptin-reactive immunoglobulins are associated with plasma leptin and markers of obesity and diabetes. Nutrition & Diabetes, Springer Nature, 2018, 8 (1), ⟨10.1038/s41387-018-0044-y⟩. ⟨hal-02315360⟩



Record views


Files downloads