Cancer and RASSF1A/RASSF1C, the two faces of Janus.

Fatéméh Dubois; Emmanuel Bergot; Guénaëlle Levallet

doi:10.1016/j.trecan.2019.10.001

Journal articles

Cancer and RASSF1A/RASSF1C, the two faces of Janus.

Fatéméh Dubois ^{1, 2} Emmanuel Bergot ^{1, 3} Guénaëlle Levallet ^{1, 2}

1 ISTCT - Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales

2 Département de Pathologie [CHU Caen]

3 Département d'oncologie thoracique et pneumologie

Hôpital Côte de Nacre [CHU Caen]

Abstract : Although encoded by the same gene, RASSF1A and RASSF1C are two opposites in carcinogenesis; one is a tumor suppressor that is silenced in a plethora of cancers, while the other is an oncogene that remains unaffected. Here, we aim to understand why and to highlight their respective clinical implications.

Keywords : RASSF1A RASSF1C cell homeostasis C1 domain carcinogenesis

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-02310265
Contributor : Carole Brunaud <>
Submitted on : Thursday, October 10, 2019 - 9:12:17 AM
Last modification on : Thursday, October 1, 2020 - 4:03:13 PM

Cancer and RASSF1A/RASSF1C, the two faces of Janus.

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