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Cancer and RASSF1A/RASSF1C, the two faces of Janus.

Fatéméh Dubois 1, 2 Emmanuel Bergot 1, 3 Guénaëlle Levallet 1, 2
1 ISTCT - Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales
2 Département de Pathologie [CHU Caen]
3 Département d'oncologie thoracique et pneumologie
Hôpital Côte de Nacre [CHU Caen]
Abstract : Although encoded by the same gene, RASSF1A and RASSF1C are two opposites in carcinogenesis; one is a tumor suppressor that is silenced in a plethora of cancers, while the other is an oncogene that remains unaffected. Here, we aim to understand why and to highlight their respective clinical implications.
Keywords : RASSF1A RASSF1C cell homeostasis C1 domain carcinogenesis
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Journal articles
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02310265
Contributor : Carole Brunaud <>
Submitted on : Thursday, October 10, 2019 - 9:12:17 AM
Last modification on : Thursday, October 1, 2020 - 4:03:13 PM

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COMUE-NORMANDIE | UNICAEN | ISTCT | ISTCT-CERVOXY | CNRS | CEA

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Fatéméh Dubois, Emmanuel Bergot, Guénaëlle Levallet. Cancer and RASSF1A/RASSF1C, the two faces of Janus.. Trends in Cancer, Cell Press, 2019, 5 (11), pp.662-665. ⟨10.1016/j.trecan.2019.10.001⟩. ⟨hal-02310265⟩

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