Cancer and RASSF1A/RASSF1C, the two faces of Janus.

Fatéméh Dubois (1, 2) , Emmanuel Bergot (1, 3) , Guénaëlle Levallet (1, 2)

1 ISTCT - Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales
2 Département de Pathologie [CHU Caen]
3 Département d'oncologie thoracique et pneumologie

Although encoded by the same gene, RASSF1A and RASSF1C are two opposites in carcinogenesis; one is a tumor suppressor that is silenced in a plethora of cancers, while the other is an oncogene that remains unaffected. Here, we aim to understand why and to highlight their respective clinical implications.

Keywords: cell homeostasis; RASSF1C; RASSF1A; C1 domain; carcinogenesis

Domains: Life Sciences [q-bio]

Fatéméh Dubois, Emmanuel Bergot, Guénaëlle Levallet. Cancer and RASSF1A/RASSF1C, the two faces of Janus.. Trends in Cancer, 2019, 5 (11), pp.662-665. ⟨10.1016/j.trecan.2019.10.001⟩. ⟨hal-02310265⟩