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Iron-Catalyzed β-Alkylation of Alcohols

Abstract : β-Branched alkylated alcohols have been prepared in good yields using a double-hydrogen autotransfer strategy in the presence of our diaminocyclopentadienone iron tricarbonyl complex Fe1. The alkylation of some 2-arylethanol derivatives was successfully addressed with benzylic alcohols and methanol as alkylating reagents under mild conditions. Deuterium labeling experiments suggested that both alcohols (2-arylethanol and either methanol or benzyl alcohol) served as hydrogen donors in this cascade process.
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Contributor : Jean-Luc Renaud <>
Submitted on : Tuesday, October 8, 2019 - 1:12:29 PM
Last modification on : Thursday, July 2, 2020 - 3:21:25 AM



Léo Bettoni, Sylvain Gaillard, Jean-Luc Renaud. Iron-Catalyzed β-Alkylation of Alcohols. Organic Letters, American Chemical Society, 2019, 21 (20), pp.8404-8408. ⟨10.1021/acs.orglett.9b03171⟩. ⟨hal-02308190⟩



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