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Journal Articles Organic Letters Year : 2019

Iron-Catalyzed β-Alkylation of Alcohols

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Abstract

β-Branched alkylated alcohols have been prepared in good yields using a double-hydrogen autotransfer strategy in the presence of our diaminocyclopentadienone iron tricarbonyl complex Fe1. The alkylation of some 2-arylethanol derivatives was successfully addressed with benzylic alcohols and methanol as alkylating reagents under mild conditions. Deuterium labeling experiments suggested that both alcohols (2-arylethanol and either methanol or benzyl alcohol) served as hydrogen donors in this cascade process.
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hal-02308190 , version 1 (08-10-2019)

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Léo Bettoni, Sylvain Gaillard, Jean-Luc Renaud. Iron-Catalyzed β-Alkylation of Alcohols. Organic Letters, 2019, 21 (20), pp.8404-8408. ⟨10.1021/acs.orglett.9b03171⟩. ⟨hal-02308190⟩
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