Glioblastoma migration along constraints with different geometries: how to mimick brain parenchyma invasion?

Mehmet Tarhan (1, 2, 3) , Alexandre Mutel (4) , Laurence Desrues (4, 5, 6) , Dominique Collard (7) , Hélène Castel (4, 5, 6)

1 IEMN - Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520
2 Yncréa Hauts-de-France
3 BIOMEMS - IEMN - Bio-Micro-Electro-Mechanical Systems - IEMN
4 DC2N - Différenciation et communication neuronale et neuroendocrine
5 DC2N - Différenciation et communication neuronale et neuroendocrine
6 Plateforme Cancer et Cognition
7 LIMMS - Laboratory for Integrated Micro Mechatronics Systems

A microfluidic device is demonstrated to analyze glioblastoma migration along constraints with precisely designed geometries. This in-vitro model reveals physiologically relevant glioma invasion scenarios: full migration along constraints, suspended motion by extreme constriction, and limited migration associated with the ejection of plasma membrane particles due to the continuing extension.

Keywords: Microfluidics; Glioblastoma; Cell migration; Mechanical constraints

Domains: Mathematics [math]; Life Sciences [q-bio]; Life Sciences [q-bio]; Cancer

Mehmet Tarhan, Alexandre Mutel, Laurence Desrues, Dominique Collard, Hélène Castel. Glioblastoma migration along constraints with different geometries: how to mimick brain parenchyma invasion?. The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2019), Oct 2019, Basel, Switzerland. ⟨hal-02303630⟩