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Glioblastoma migration along constraints with different geometries: how to mimick brain parenchyma invasion?

Mehmet Tarhan 1, 2, 3 Alexandre Mutel 4 Laurence Desrues 4, 5, 6 Dominique Collard 7 Hélène Castel 4, 5, 6 
1 IEMN - Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520
2 Yncréa Hauts-de-France
3 BIOMEMS - IEMN - Bio-Micro-Electro-Mechanical Systems - IEMN
IEMN - Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520
4 DC2N - Différenciation et communication neuronale et neuroendocrine
5 DC2N - Différenciation et communication neuronale et neuroendocrine
6 Plateforme Cancer et Cognition
7 LIMMS - Laboratory for Integrated Micro Mechatronics Systems
Abstract : A microfluidic device is demonstrated to analyze glioblastoma migration along constraints with precisely designed geometries. This in-vitro model reveals physiologically relevant glioma invasion scenarios: full migration along constraints, suspended motion by extreme constriction, and limited migration associated with the ejection of plasma membrane particles due to the continuing extension.
Keywords : Microfluidics Glioblastoma Cell migration Mechanical constraints
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Submitted on : Friday, November 15, 2019 - 12:04:04 PM
Last modification on : Tuesday, April 26, 2022 - 3:50:01 PM
Long-term archiving on: : Sunday, February 16, 2020 - 3:37:51 PM

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  • HAL Id : hal-02303630, version 1

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CNRS | UNIV-VALENCIENNES | IEMN | INSMI | COMUE-NORMANDIE | LIMMS | UNIROUEN | UNIV-LILLE | DC2N

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Mehmet Tarhan, Alexandre Mutel, Laurence Desrues, Dominique Collard, Hélène Castel. Glioblastoma migration along constraints with different geometries: how to mimick brain parenchyma invasion?. The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2019), Oct 2019, Basel, Switzerland. ⟨hal-02303630⟩

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