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Glioblastoma migration along constraints with different geometries: how to mimick brain parenchyma invasion?

Abstract : A microfluidic device is demonstrated to analyze glioblastoma migration along constraints with precisely designed geometries. This in-vitro model reveals physiologically relevant glioma invasion scenarios: full migration along constraints, suspended motion by extreme constriction, and limited migration associated with the ejection of plasma membrane particles due to the continuing extension.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02303630
Contributor : Hélène Castel <>
Submitted on : Friday, November 15, 2019 - 12:04:04 PM
Last modification on : Tuesday, April 7, 2020 - 3:36:04 PM
Long-term archiving on: : Sunday, February 16, 2020 - 3:37:51 PM

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Mehmet Tarhan, Alexandre Mutel, Laurence Desrues, Dominique Collard, Hélène Castel. Glioblastoma migration along constraints with different geometries: how to mimick brain parenchyma invasion?. The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2019), Oct 2019, Basel, Switzerland. ⟨hal-02303630⟩

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