Glioblastoma migration along constraints with different geometries: how to mimick brain parenchyma invasion?

Mehmet Tarhan 1 Alexandre Mutel 2 Laurence Desrues 2, 3, 4 Dominique Collard 5 Hélène Castel 2, 3, 4
1 UMR 8520 - IEMN, Lille, France
2 DC2N - Différenciation et communication neuronale et neuroendocrine
3 DC2N - Différenciation et communication neuronale et neuroendocrine
4 Cancer and Cognition Platform, Ligue Nationale contre le cancer,14000Caen, France
5 LIMMS - Laboratory for Integrated Micro Mechatronics Systems
Abstract : A microfluidic device is demonstrated to analyze glioblastoma migration along constraints with precisely designed geometries. This in-vitro model reveals physiologically relevant glioma invasion scenarios: full migration along constraints, suspended motion by extreme constriction, and limited migration associated with the ejection of plasma membrane particles due to the continuing extension.
Keywords : Microfluidics Glioblastoma Cell migration Mechanical constraints
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Communication dans un congrès
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Soumis le : vendredi 15 novembre 2019 - 12:04:04
Dernière modification le : mercredi 20 novembre 2019 - 10:00:39

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COMUE-NORMANDIE | INSMI | CNRS | LIMMS | UNIROUEN | DC2N

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Mehmet Tarhan, Alexandre Mutel, Laurence Desrues, Dominique Collard, Hélène Castel. Glioblastoma migration along constraints with different geometries: how to mimick brain parenchyma invasion?. The 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2019), Oct 2019, Basel, Switzerland. ⟨hal-02303630⟩

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