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Glutamine and the regulation of intestinal permeability

Najate Achamrah 1, 2, 3, 4 Pierre Dechelotte 1, 2, 3, 4 Moïse Coëffier 1, 2, 3, 4
1 ADEN - Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau
2 Service de nutrition [CHU Rouen]
3 IRIB - Institute for Research and Innovation in Biomedicine
4 UNIROUEN - Université de Rouen Normandie
Abstract : Glutamine is a major nutrient to maintain intestinal barrier function in animals and humans. Depletion of glutamine results in villus atrophy, decreased expression of tight junction proteins and increased intestinal permeability. Moreover, glutamine supplementation can improve gut barrier function in several experimental conditions of injury and in some clinical situations. Furthermore, preventive effects of glutamine in experimental models of intestinal injuries have been recently reported. Despite promising data in experimental models, further studies are needed to evaluate glutamine supplementation in clinical practice.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02301373
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Submitted on : Monday, September 30, 2019 - 1:39:26 PM
Last modification on : Thursday, July 2, 2020 - 3:42:22 AM

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COMUE-NORMANDIE | ADEN | UNIROUEN | CNRS

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Najate Achamrah, Pierre Dechelotte, Moïse Coëffier. Glutamine and the regulation of intestinal permeability. Current Opinion in Clinical Nutrition and Metabolic Care, Lippincott, Williams & Wilkins, 2017, 20 (1), pp.86-91. ⟨10.1097/MCO.0000000000000339⟩. ⟨hal-02301373⟩

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