Selective Heart Rate Reduction Improves Metabolic Syndrome–related Left Ventricular Diastolic Dysfunction

Nassiba Merabet (1) , Yuehua Fang (2) , Lionel Nicol (3) , Christelle Monteil (4) , Isabelle Remy-Jouet (5) , Jean-Paul Henry (5) , Didier Wecker (6) , Sabrina Le Bouter-Banon (7) , Jérôme Roussel (7) , Vincent Richard (8) , Christian Thuillez (2) , Paul Mulder (3, 5)

1 Montreal Heart Institute - Institut de Cardiologie de Montréal
2 Pharmacologie des Dysfonctionnements Endotheliaux et Myocardiques
3 IRIB - Institute for Research and Innovation in Biomedicine
4 ABTE - Aliments Bioprocédés Toxicologie Environnements
5 EnVI - Endothélium, valvulopathies et insuffisance cardiaque
6 Bruker BioSpin MRI GmbH [Ettlingen, Germany]
7 IRIS - Institut de Recherches Internationales Servier [Suresnes]
8 Institut Pasteur de Dakar

Enhanced heart rate observed in metabolic syndrome (MS) contributes to the deterioration of left ventricular (LV) function via impaired LV filling and relaxation, increased myocardial O2 consumption, and reduced coronary perfusion. However, whether heart rate reduction (HRR) opposes LV dysfunction observed in MS is unknown.

Keywords: heart rate reduction; diastolic function; metabolic syndrome

Domains: Life Sciences [q-bio]; Human health and pathology; Cardiology and cardiovascular system; Life Sciences [q-bio]; Human health and pathology; Tissues and Organs [q-bio.TO]

Nassiba Merabet, Yuehua Fang, Lionel Nicol, Christelle Monteil, Isabelle Remy-Jouet, et al.. Selective Heart Rate Reduction Improves Metabolic Syndrome–related Left Ventricular Diastolic Dysfunction. Journal of Cardiovascular Pharmacology, 2015, 66 (4), pp.399-408. ⟨10.1097/FJC.0000000000000294⟩. ⟨hal-02300715⟩