How to assess and manage cognitive impairment induced by treatments of non-central nervous system cancer

Marie Lange (1, 2, 3) , Hélène Castel (4, 3) , Johan Le Fel (5) , Laure Tron (6, 3) , Didier Maillet (7, 8) , Myriam Bernaudin (9) , Omar Touzani (9) , Joy Perrier (10) , Mathieu Boone (11) , Idlir Licaj (2, 3) , Bénédicte Giffard (10, 3) , Martine Dubois (4) , Olivier Rigal (5) , Thomas Durand (12) , Catherine Belin (13) , Damien Ricard (12) , Rozenn Le Gal (9) , Véronique Pancré (14) , Isabelle Hardy-Léger (15) , Florence Joly (1, 2, 16, 3)

1 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
2 ANTICIPE - Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers
3 Plateforme Cancer et Cognition
4 IRIB - Institute for Research and Innovation in Biomedicine
5 CLCC Henri Becquerel - Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen
6 CHU Caen
7 PSITEC - Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072
8 Hôpital Côte de Nacre [CHU Caen]
9 ISTCT - Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales
10 NIMH - Neuropsychologie et imagerie de la mémoire humaine
11 CHU Amiens-Picardie
12 COGNAC-G - UMR 8257 - Cognition and Action Group
13 AP-HP - Hopital Saint-Louis [AP-HP]
14 Cancéropole Nord-Ouest
15 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
16 Service d'Oncologie médicale [CHU Caen]

A number of neurotoxicity associated with oncological treatments has been reported in non-central nervous system cancers.An expert group presents the state of the art and a guide to help the choice of appropriated tools to assess patient cognition in studies on oncology and neurobehavior in animal models. In addition, current cognitive rehabilitation programs currently under evaluation are also discussed.Cognitive assessments in oncology depend on the research question, study design, cognitive domains, patients’ characteristics, psychometric properties of the tests, and whether the tests are supervised or not by a neuropsychologist. Batteries of electronic tests can be proposed, but several of them are characterized by weak psychometric developments. In order to improve the comprehension on the impact of cancer treatments on cognition, new animal models are in development, and would in the future include non-human primate models.By bringing together the skills and practices of oncologists, neurologists, neuropsychologists, neuroscientists, we propose a series of specific tools and tests that accompany the cognitive management of non-CNS cancer patients.

Keywords: Animal model; Electronic cognitive tests; Cancer patients; Cancer treatments; Cognition; Behavior; Management of cognitive impairment

Domains: Life Sciences [q-bio]

Marie Lange, Hélène Castel, Johan Le Fel, Laure Tron, Didier Maillet, et al.. How to assess and manage cognitive impairment induced by treatments of non-central nervous system cancer. Neuroscience and Biobehavioral Reviews, 2019, 107, pp.602-614. ⟨10.1016/j.neubiorev.2019.09.028⟩. ⟨hal-02297897⟩