How to assess and manage cognitive impairment induced by treatments of non-central nervous system cancer

Marie Lange; Hélène Castel; Johan Le Fel; Laure Tron; Didier Maillet; Myriam Bernaudin; Omar Touzani; Joy Perrier; Mathieu Boone; Idlir Licaj; Bénédicte Giffard; Martine Dubois; Olivier Rigal; Thomas Durand; Catherine Belin; Damien Ricard; Rozenn Le Gal; Véronique Pancré; Isabelle Hardy-Léger; Florence Joly

doi:10.1016/j.neubiorev.2019.09.028

Article dans une revue

How to assess and manage cognitive impairment induced by treatments of non-central nervous system cancer

Marie Lange ^{1, 2, 3} Hélène Castel ^{3, 4} Johan Le Fel ⁵ Laure Tron ^{3, 6} Didier Maillet ^{7, 8} Myriam Bernaudin ⁹ Omar Touzani ⁹ Joy Perrier ¹⁰ Mathieu Boone ¹¹ Idlir Licaj ^{2, 3} Bénédicte Giffard ^{3, 10} Martine Dubois ⁴ Olivier Rigal ⁵ Thomas Durand ¹² Catherine Belin ⁷ Damien Ricard ¹² Rozenn Le Gal ⁹ Véronique Pancré ¹³ Isabelle Hardy-Léger ¹⁴ Florence Joly ^{1, 2, 3, 15}

1 CRLC François Baclesse - Centre Régional de Lutte contre le Cancer François Baclesse

2 ANTICIPE - Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers

3 Plateforme Cancer et Cognition [Caen]

4 IRIB - Institute for Research and Innovation in Biomedicine

5 CLCC Henri Becquerel - Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen

6 CHU Caen

7 Département Neurologie

8 PSITEC - Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - EA 4072

9 ISTCT - Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales

10 NIMH - Neuropsychologie et imagerie de la mémoire humaine

11 Département d'oncologie, CHU Amiens

12 COGNAC-G - UMR 8257 - Cognition and Action Group

13 Cancéropole Nord-Ouest

14 NeuroHIV Rehabilitation Unit [Le Kremlin-Bicêtre]

15 Service d'Oncologie médicale [CHU Caen]

Abstract : A number of neurotoxicity associated with oncological treatments has been reported in non-central nervous system cancers. An expert group presents the state of the art and a guide to help the choice of appropriated tools to assess patient cognition in studies on oncology and neurobehavior in animal models. In addition, current cognitive rehabilitation programs currently under evaluation are also discussed. Cognitive assessments in oncology depend on the research question, study design, cognitive domains, patients’ characteristics, psychometric properties of the tests, and whether the tests are supervised or not by a neuropsychologist. Batteries of electronic tests can be proposed, but several of them are characterized by weak psychometric developments. In order to improve the comprehension on the impact of cancer treatments on cognition, new animal models are in development, and would in the future include non-human primate models. By bringing together the skills and practices of oncologists, neurologists, neuropsychologists, neuroscientists, we propose a series of specific tools and tests that accompany the cognitive management of non-CNS cancer patients.

Keywords : Cognition Cancer treatments Cancer patients Electronic cognitive tests Animal model Behavior Management of cognitive impairment

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Sciences du Vivant [q-bio]

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https://hal-normandie-univ.archives-ouvertes.fr/hal-02297897
Contributeur : Carole Brunaud <>
Soumis le : jeudi 26 septembre 2019 - 15:39:33
Dernière modification le : lundi 27 avril 2020 - 15:56:04

How to assess and manage cognitive impairment induced by treatments of non-central nervous system cancer

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