J. O. Archambeau, R. Pezner, and T. Wasserman, Pathophysiology of irradiated skin and breast, Int. J. Radiat. Oncol. Biol. Phys, vol.31, pp.1171-1185, 1995.

B. Dubray, S. Delanian, and J. L. Lefaix, Late effects of mammary radiotherapy on skin and subcutaneous tissues, Cancer Radiother, vol.1, pp.744-752, 1997.

R. U. Peter and P. Gottlober, Management of cutaneous radiation injuries: Diagnostic and therapeutic principles of the cutaneous radiation syndrome, Mil. Med, vol.167, pp.110-112, 2002.

K. Masuda, N. Hunter, and H. R. Withers, Late effect in mouse skin following single and multifractionated irradiation, Int. J. Radiat. Oncol. Biol. Phys, vol.6, pp.1539-1544, 1980.

P. Rubin and G. W. Casarett, Clinical radiation pathology as applied to curative radiotherapy, Cancer, vol.22, pp.767-778, 1968.

P. Rubin, The Franz Buschke lecture: Late effects of chemotherapy and radiation therapy: A new hypothesis, Int. J. Radiat. Oncol. Biol. Phys, vol.10, pp.5-34, 1984.

J. E. Moulder, M. E. Robbins, E. P. Cohen, J. W. Hopewell, and W. F. Ward, Pharmacologic modification of radiation-induced late normal tissue injury, Cancer Treat. Res, vol.93, pp.129-151, 1998.

K. R. Trott, Experimental radiotherapy of late-responding tissuesrecent advances and future development, Front. Radiat. Ther. Oncol, vol.37, pp.9-16, 2002.

H. B. Stone, W. H. Mcbride, and C. N. Coleman, Report of a workshop sponsored by the Radiation Research Program, National Cancer Institute, Radiat. Res, vol.157, pp.204-223, 2000.

M. C. Vozenin-brotons, V. Sivan, N. Gault, C. Renard, C. Geffrotin et al., Antifibrotic action of Cu/ Zn SOD is mediated by TGF-?1 repression and phenotypic reversion of myofibroblasts. Free Radic, Biol. Med, vol.30, pp.30-42, 2001.

J. L. Lefaix, S. Delanian, J. J. Leplat, Y. Tricaud, M. Martin et al., Successful treatment of radiationinduced fibrosis using Cu/Zn-SOD and Mn-SOD: An experimental study, Int. J. Radiat. Oncol. Biol. Phys, vol.35, pp.305-312, 1996.

S. Delanian, F. Baillet, J. Huart, J. L. Lefaix, C. Maulard et al., Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: Clinical trial, Radiother. Oncol, vol.32, pp.12-20, 1994.

J. P. Freitas, P. Filipe, and F. Guerra-rodrigo, Potential antioxidative effects of pentoxifylline, C. R. Seances Soc. Biol. Fil, vol.189, pp.401-405, 1995.

B. Horvath, Z. Marton, R. Halmosi, T. Alexy, L. Szapary et al., In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine, Clin. Neuropharmacol, vol.25, pp.37-42, 2002.

C. E. Rube, F. Wilfert, D. Uthe, K. W. Schmid, R. Knoop et al., Modulation of radiation-induced tumour necrosis factor alpha (TNF-?) expression in the lung tissue by pentoxifylline, Radiother. Oncol, vol.64, pp.177-187, 2002.

K. J. Russell, L. W. Wiens, G. W. Demers, D. A. Galloway, T. Le et al., Preferential radiosensitization of G 1 checkpoint-deficient cells by methylxanthines, Int. J. Radiat. Oncol. Biol. Phys, vol.36, pp.1099-1106, 1996.

A. M. Strunz, P. Peschke, W. Waldeck, V. Ehemann, M. Kissel et al., Preferential radiosensitization in p53-mutated human tumour cell lines by pentoxifylline-mediated disruption of the G 2 /M checkpoint control, Int. J. Radiat. Biol, vol.78, pp.721-732, 2002.

K. W. Eley, S. H. Benedict, T. D. Chung, B. D. Kavanagh, W. C. Broaddus et al., The effects of pentoxifylline on the survival of human glioma cells with continuous and intermittent stereotactic radiosurgery irradiation, Int. J. Radiat. Oncol. Biol. Phys, vol.54, pp.542-550, 2002.

T. Theron, A. Binder, F. Verheye-dua, and L. Bohm, The role of G 2 -block abrogation, DNA double-strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines by pentoxifylline, Int. J. Radiat. Biol, vol.76, pp.1197-1208, 2000.

A. Binder, T. Theron, H. Donninger, M. Parker, and L. Bohm, Radiosensitization and DNA repair inhibition by pentoxifylline in NIH3T3 p53 transfectants, Int. J. Radiat. Biol, vol.78, pp.991-1000, 2002.

#. File and . 01tq,

J. N. Sarkaria and J. S. Eshleman, ATM as a target for novel radiosensitizers, Semin. Radiat. Oncol, vol.11, pp.316-327, 2001.

E. Bozsakyova, I. Chalupa, L. Sebova, and D. Slamenova, Chromosomal aberrations, sister chromatid exchanges and micronuclei induced by pentoxifylline in in vitro cultivated Chinese hamster cells (V79) and human blood lymphocytes, Mutat. Res, vol.497, pp.63-70, 2001.

M. W. Dion, D. H. Hussey, and J. W. Osborne, The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice, Int. J. Radiat. Oncol. Biol. Phys, vol.17, pp.101-107, 1989.

W. J. Koh, K. J. Stelzer, L. M. Peterson, B. L. Staker, W. F. Ward et al., Effect of pentoxifylline on radiationinduced lung and skin toxicity in rats, Int. J. Radiat. Oncol. Biol. Phys, vol.31, pp.71-77, 1995.

M. W. Dion, D. H. Hussey, J. F. Doornbos, A. P. Vigliotti, B. C. Wen et al., Preliminary results of a pilot study of pentoxifylline in the treatment of late radiation soft tissue necrosis, Int. J. Radiat. Oncol. Biol. Phys, vol.19, pp.401-407, 1990.

B. Ozturk, I. Egehan, S. Atavci, and M. Kitapci, Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: A double-blind randomized trial, Int. J. Radiat. Oncol. Biol. Phys, vol.58, pp.213-219, 2004.

W. F. Ward, Y. T. Kim, A. Molteni, C. , and J. M. Hinz, Pentoxifylline does not spare acute radiation reactions in rat lung and skin, Radiat. Res, vol.129, pp.107-111, 1992.

J. L. Lefaix, S. Delanian, M. C. Vozenin, J. J. Leplat, Y. Tricaud et al., Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: An experimental study, Int. J. Radiat. Oncol. Biol. Phys, vol.43, pp.839-847, 1999.

S. Delanian, R. Porcher, S. Balla-mekias, and J. L. Lefaix, Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis, J. Clin. Oncol, vol.21, pp.2545-2550, 2003.

G. Rimbach, A. M. Minihane, J. Majewicz, A. Fischer, J. Pallauf et al., Regulation of cell signalling by vitamin E, Proc. Nutr. Soc, vol.61, pp.415-425, 2002.

S. F. Sweetman, J. J. Strain, and V. J. Mckelvey-martin, Effect of antioxidant vitamin supplementation on DNA damage and repair in human lymphoblastoid cells, Nutr. Cancer, vol.27, pp.122-130, 1997.

B. Kumar, M. N. Jha, W. C. Cole, J. S. Bedford, and K. N. Prasad, D-Alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells, J. Am. Coll. Nutr, vol.21, pp.339-343, 2002.

L. Sarma and P. C. Kesavan, Protective effects of vitamins C and E against gamma-ray-induced chromosomal damage in mouse, Int. J. Radiat. Biol, vol.63, pp.759-764, 1993.

M. Satyamitra, P. Devi, H. Murase, and V. T. Kagiya, In vivo postirradiation protection by a vitamin E analog, ?-TMG, Radiat. Res, vol.160, pp.655-661, 2003.

H. V. Worthington, J. E. Clarkson, and O. B. Eden, Interventions for treating oral mucositis for patients with cancer receiving treatment, Cochrane Database Syst. Rev, p.1973, 2002.

S. Delanian, S. Balla-mekias, and J. L. Lefaix, Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol, J. Clin. Oncol, vol.17, pp.3283-3290, 1999.

H. Letur-konirsch, F. Guis, and S. Delanian, Uterine restoration by radiation sequelae regression with combined pentoxifylline-tocopherol: A phase II study, Fertil. Steril, vol.77, pp.1219-1226, 2002.

S. Delanian and J. L. Lefaix, Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate, Br. J. Radiol, vol.75, pp.467-469, 2002.

G. Cao, H. M. Alessio, and R. G. Cutler, Oxygen-radical absorbance capacity assay for antioxidants. Free Radic, Biol. Med, vol.14, pp.303-311, 1993.

T. T. Puck, P. I. Marcus, and S. J. Cieciura, Clonal growth of mammalian cells in vitro; Growth characteristics of colonies from single HeLa cells with and without a feeder layer, J. Exp. Med, vol.103, pp.273-283, 1956.

J. P. Pouget, T. Douki, M. J. Richard, and J. Cadet, DNA damage induced in cells by gamma and UVA radiation as measured by HPLC/GC-MS and HPLC-EC and Comet assay, Chem. Res. Toxicol, vol.13, pp.541-549, 2000.
URL : https://hal.archives-ouvertes.fr/hal-02054396

C. P. Lebel, H. Ischiropoulos, and S. C. Bondy, Evaluation of the probe 2?,7?-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress, Chem. Res. Toxicol, vol.5, pp.227-231, 1992.

J. N. Sarkaria, E. C. Busby, R. S. Tibbetts, P. Roos, Y. Taya et al., Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine, Cancer Res, vol.59, pp.4375-4382, 1999.

M. R. Lieber, Y. Ma, U. Pannicke, and K. Schwarz, Mechanism and regulation of human non-homologous DNA end-joining, Nat. Rev. Mol. Cell. Biol, vol.4, pp.712-720, 2003.