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Journal articles
Identification of Ras, Pten and p70S6K homologs in the Pacific oyster Crassostrea gigas and diet control of insulin pathway
Abstract : Insulin pathways were demonstrated from invertebrates to vertebrates to be involved in the regulation of numerous processes including storage metabolism and reproduction. In addition, insulin system may integrate variations of environmental conditions like dietary restrictions. In the Pacific oyster Crassostrea gigas, reproductive and storage compartments are closely intricated in the gonadal area and their respective development was found to be dependant of trophic conditions. For these reasons, C. gigas is an original and interesting model for investigating the role of insulin control in the balance between storage and reproduction and the integration of environmental parameters. On the basis of sequence conservation, we identified three potential elements of the oyster insulin pathway, Ras, Pten and p70S6K and we investigated their expression levels in various tissues. In the gonadal area, we used laser microdissection in order to precise the targeted contribution of insulin signaling to the restoration of storage tissue and to the control of vitellogenesis. Food deprivation during gametogenesis reinitiation stage led to reduced proliferations of gonia and also to modulate insulin signal by transcriptional activation of insulin pathway elements.
https://hal-normandie-univ.archives-ouvertes.fr/hal-02296527
Contributor : Pascal Sourdaine <>
Submitted on : Wednesday, September 25, 2019 - 11:51:06 AM
Last modification on : Tuesday, April 7, 2020 - 4:28:46 PM
Contributor : Pascal Sourdaine <>
Submitted on : Wednesday, September 25, 2019 - 11:51:06 AM
Last modification on : Tuesday, April 7, 2020 - 4:28:46 PM
