Skip to Main content Skip to Navigation
Journal articles

Ghrelin treatment prevents development of activity based anorexia in mice

Romain Legrand 1, 2 Nicolas Lucas 1, 2 Jonathan Breton 1, 2 Saïda Azhar 1, 2 Jean-Claude Do Rego 3, 2 Pierre Dechelotte 1, 2, 4 Moïse Coëffier 1, 2, 4 Sergueï O. Fetissov 1, 2 
3 SCAC - Service Commun d'Analyse Comportementale
UNIROUEN - Université de Rouen Normandie, IRIB - Institute for Research and Innovation in Biomedicine, HeRacLeS - High-tech Research Infrastructures for Life Sciences
Abstract : Stimulation of feeding is necessary for treatment of pathological conditions of chronic malnutrition due to anorexia. Ghrelin, a hunger hormone, is one of the candidate for pharmacological treatments of anorexia, but because of its instability in plasma has limited efficacy. We previously showed that plasmatic IgG protect ghrelin from degradation and that IgG from obese subjects and mice may increase ghrelin׳s orexigenic effect. In this study we tested if ghrelin alone or combined with IgG may improve feeding in chronically food-restricted mice with or without physical activity-based anorexia (ABA) induced by free access to a running wheel. Mice received a single daily intraperitoneal injection of ghrelin (1 nM) together or not with total IgG (1 nM) from obese ob/ob or lean mice before access to food during 8 days of 3 h/day feeding time. We found that both ghrelin and ghrelin combined with IgG from obese, but not lean mice, prevented ABA, however, they were not able to diminish body weight loss. Physical activity was lower during the feeding period and was increased shortly after feeding in mice receiving ghrelin together with IgG from obese mice. In food-restricted mice without ABA, ghrelin treatments did not have significant effects on food intake. Thus, this study supports pharmacological use of ghrelin or ghrelin combined with IgG from obese animals for treatment of anorexia accompanied by elevated physical activity. The utility of combining ghrelin with protective IgG should be further determined in animal models of anorexia with unrestricted access to food.
Document type :
Journal articles
Complete list of metadata
Contributor : sabine douville Connect in order to contact the contributor
Submitted on : Tuesday, September 24, 2019 - 2:51:05 PM
Last modification on : Wednesday, September 7, 2022 - 9:23:30 AM




Romain Legrand, Nicolas Lucas, Jonathan Breton, Saïda Azhar, Jean-Claude Do Rego, et al.. Ghrelin treatment prevents development of activity based anorexia in mice. European Neuropsychopharmacology, Elsevier, 2016, 26 (6), pp.948-958. ⟨10.1016/j.euroneuro.2016.03.010⟩. ⟨hal-02295806⟩



Record views