Université Lille Nord de France (COMUE) (COMUE Communauté d'universités et établissements Lille-Nord-de-France -
- 365 bis, rue Jules Guesde BP 50458 - 59658 Villeneuve d’Ascq Cedex
- (A succédé au PRES Université de Lille Nord de France) - France)
Abstract : Anorexia nervosa (AN) is classically defined as a condition in which an abnormally low body weight is associated with an intense fear of gaining weight and distorted cognitions regarding weight, shape, and drive for thinness. This article reviews recent evidences from physiology, genetics, epigenetics, and brain imaging which allow to consider AN as an abnormality of reward pathways or an attempt to preserve mental homeostasis. Special emphasis is put on ghrelino-resistance and the importance of orexigenic peptides of the lateral hypothalamus, the gut microbiota and a dysimmune disorder of neuropeptide signaling. Physiological processes, secondary to underlying, and premorbid vulnerability factors—the “pondero-nutritional-feeding basements”- are also discussed.
https://hal-normandie-univ.archives-ouvertes.fr/hal-02295593 Contributor : sabine douvilleConnect in order to contact the contributor Submitted on : Wednesday, April 1, 2020 - 11:48:16 AM Last modification on : Friday, August 5, 2022 - 11:23:56 AM
Philip Gorwood, Corinne Blanchet-Collet, Nicolas Chartrel, Jeanne Duclos, Pierre Dechelotte, et al.. New Insights in Anorexia Nervosa. Frontiers in Neuroscience, Frontiers, 2016, 10, ⟨10.3389/fnins.2016.00256⟩. ⟨hal-02295593⟩