Skip to Main content Skip to Navigation
Journal articles

Imaging modalities to assess oxygen status in glioblastoma

Abstract : Hypoxia, the result of an inadequacy between a disorganized and functionally impaired vasculature and the metabolic demand of tumor cells, is a feature of glioblastoma. Hypoxia promotes the aggressiveness of these tumors and, equally, negatively correlates with a decrease in outcome. Tools to characterize oxygen status are essential for the therapeutic management of patients with glioblastoma (i) to refine prognosis, (ii) to adapt the treatment regimen, and (iii) to assess the therapeutic efficacy. While methods that are focal and invasive in nature are of limited use, non-invasive imaging technologies have been developed. Each of these technologies is characterized by its singular advantages and limitations in terms of oxygenation status in glioblastoma. The aim of this short review is, first, to focus on the interest to characterize hypoxia for a better therapeutic management of patients and, second, to discuss recent and pertinent approaches for the assessment of oxygenation/hypoxia and their direct implication for patient care.
Complete list of metadatas

Cited literature [31 references]  Display  Hide  Download

https://hal-normandie-univ.archives-ouvertes.fr/hal-02292354
Contributor : Florence Couteau <>
Submitted on : Tuesday, October 29, 2019 - 12:39:11 PM
Last modification on : Monday, April 27, 2020 - 3:56:04 PM
Document(s) archivé(s) le : Thursday, January 30, 2020 - 5:11:01 PM

File

fmed-02-00057.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Aurélien Corroyer-Dulmont, Ararat Chakhoyan, Solène Collet, Lucile Durand, Eric T. Mackenzie, et al.. Imaging modalities to assess oxygen status in glioblastoma. Frontiers in Medicine, Frontiers media, 2015, 2, pp.57. ⟨10.3389/fmed.2015.00057⟩. ⟨hal-02292354⟩

Share

Metrics

Record views

85

Files downloads

153