Regioselective Pd-Catalyzed Carbopalladation/Decarboxylative Allylic Alkynylation of ortho -Iodoallenamides with Alkynyl Carboxylic Acids - Normandie Université Accéder directement au contenu
Article Dans Une Revue Journal of Organic Chemistry Année : 2019

Regioselective Pd-Catalyzed Carbopalladation/Decarboxylative Allylic Alkynylation of ortho -Iodoallenamides with Alkynyl Carboxylic Acids

Résumé

A regioselective Pd-catalyzed domino carbopalladation/decarboxylative allylic alkynylation of ortho-iodoallenamides with alkynyl carboxylic acids was studied. This domino process, based on the consecutive formation of C(sp2)–C(sp2) and C(sp3)–C(sp) bonds, was originally achieved for the design of a novel library of prop-2-ynyl isoquinolinones and then extended to indoles. Finally, a general three-step one-pot strategy involving in situ generation of allenamide, π-allyl-Pd complex formation, and decarboxylative allylic alkynylation was subsequently set up.

Domaines

Chimie
Fichier non déposé

Dates et versions

hal-02282525 , version 1 (10-09-2019)

Identifiants

Citer

Jonathan Hédouin, Vincent Carpentier, Romain Renard, Cédric Schneider, Isabelle Gillaizeau, et al.. Regioselective Pd-Catalyzed Carbopalladation/Decarboxylative Allylic Alkynylation of ortho -Iodoallenamides with Alkynyl Carboxylic Acids. Journal of Organic Chemistry, 2019, 84 (16), pp.10535-10545. ⟨10.1021/acs.joc.9b01408⟩. ⟨hal-02282525⟩
54 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More