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Catalytic Asymmetric Synthesis of α,α-Difluoromethylated and α-Fluoromethylated Tertiary Alcohols

Abstract : The catalytic asymmetric synthesis of α,α-difluoromethylated tertiary alcohols is described, using an asymmetric dihydroxylation reaction. This protocol using either the AD-mix-α or AD-mix-β allowed an easy access to these valuable fluorinated chiral building blocks, which have been obtained with excellent yields and er. In addition, the reaction was extended to the α-fluoromethylated analogues.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02282518
Contributor : Madeleine Roux-Merlin <>
Submitted on : Tuesday, September 10, 2019 - 9:48:49 AM
Last modification on : Thursday, July 2, 2020 - 3:28:32 AM

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Wei-Sheng Huang, Marie-Léonie Delcourt, Xavier Pannecoucke, André Charette, Thomas Poisson, et al.. Catalytic Asymmetric Synthesis of α,α-Difluoromethylated and α-Fluoromethylated Tertiary Alcohols. Organic Letters, American Chemical Society, 2019, 21 (18), pp.7509-7513. ⟨10.1021/acs.orglett.9b02792⟩. ⟨hal-02282518⟩

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