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The Hypothalamic–Pituitary–Adrenal Axis and Anesthetics

Abstract : The hypothalamic–pituitary–adrenal (HPA) axis is essential for human adaptation to stress. However, many anesthetic agents may interfere with the activity of this axis. Although etomidate is known for its suppressive effect on HPA axis function, in vitro evidence suggests that many other drugs used in anesthesia care may also interfere with HPA activity. In this review, we discuss the mechanisms by which all HPA axis activity may be altered during anesthesia and critical care and focus on the impact of hypnotic and analgesic drugs.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02280499
Contributor : Hélène Castel <>
Submitted on : Friday, September 6, 2019 - 1:43:58 PM
Last modification on : Tuesday, April 7, 2020 - 3:36:04 PM

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Emmanuel Besnier, Thomas Clavier, Vincent Compère. The Hypothalamic–Pituitary–Adrenal Axis and Anesthetics. Anesthesia and Analgesia, Lippincott, Williams & Wilkins, 2017, 124 (4), pp.1181-1189. ⟨10.1213/ANE.0000000000001580⟩. ⟨hal-02280499⟩

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