The Hypothalamic–Pituitary–Adrenal Axis and Anesthetics

Abstract : The hypothalamic–pituitary–adrenal (HPA) axis is essential for human adaptation to stress. However, many anesthetic agents may interfere with the activity of this axis. Although etomidate is known for its suppressive effect on HPA axis function, in vitro evidence suggests that many other drugs used in anesthesia care may also interfere with HPA activity. In this review, we discuss the mechanisms by which all HPA axis activity may be altered during anesthesia and critical care and focus on the impact of hypnotic and analgesic drugs.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-normandie-univ.archives-ouvertes.fr/hal-02280499
Contributeur : Hélène Castel <>
Soumis le : vendredi 6 septembre 2019 - 13:43:58
Dernière modification le : mardi 24 septembre 2019 - 09:45:22

Identifiants

Collections

Citation

Emmanuel Besnier, Thomas Clavier, Vincent Compère. The Hypothalamic–Pituitary–Adrenal Axis and Anesthetics. Anesthesia and Analgesia, Lippincott, Williams & Wilkins, 2017, 124 (4), pp.1181-1189. ⟨10.1213/ANE.0000000000001580⟩. ⟨hal-02280499⟩

Partager

Métriques

Consultations de la notice

14