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Article Dans Une Revue Chemistry - A European Journal Année : 2019

Copper‐Photocatalyzed Borylation of Organic Halides under Batch and Continuous‐Flow Conditions

Résumé

The copper‐photocatalyzed borylation of aryl, heteroaryl, vinyl and alkyl halides (I and Br) was reported. The reaction proceeded using a new heteroleptic Cu complex under irradiation with blue LEDs, giving the corresponding boronic‐acid esters in good to excellent yields. The reaction was extended to continuous‐flow conditions to allow an easy scale‐up. The mechanism of the reaction was studied and a mechanism based on a reductive quenching (CuI/CuI*/Cu0) was suggested.

Domaines

Chimie
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Dates et versions

hal-02278783 , version 1 (04-09-2019)

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Citer

Antoine Nitelet, Damien Thevenet, Bruno Schiavi, Christophe Hardouin, Jean Fournier, et al.. Copper‐Photocatalyzed Borylation of Organic Halides under Batch and Continuous‐Flow Conditions. Chemistry - A European Journal, 2019, 25 (13), pp.3262-3266. ⟨10.1002/chem.201806345⟩. ⟨hal-02278783⟩
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