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Access to Isothiazolones from Simple Acrylamides by Pd-Catalyzed C–H Bond Activation

Abstract : A new methodology was developed to access isothiazolone derivatives from simple acrylamides by transition metal catalyzed C–H bond functionalization. This Pd-catalyzed reaction using an electrophilic SCN source offered an efficient tool to access a panel of functionalized isothiazolone derivatives (21 examples, up to 71% yield).
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02267936
Contributor : Tatiana Besset <>
Submitted on : Thursday, September 5, 2019 - 3:47:25 PM
Last modification on : Thursday, July 2, 2020 - 3:29:53 AM
Long-term archiving on: : Thursday, February 6, 2020 - 6:28:44 AM

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Mu-Yi Chen, Xavier Pannecoucke, Philippe Jubault, Tatiana Besset. Access to Isothiazolones from Simple Acrylamides by Pd-Catalyzed C–H Bond Activation. Journal of Organic Chemistry, American Chemical Society, In press, 84 (20), pp.13194-13202. ⟨10.1021/acs.joc.9b01872⟩. ⟨hal-02267936⟩

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