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Journal articles
Regio- and Chemoselective Deprotection of Primary Acetates by Zirconium Hydrides
Abstract : A combination of DIBAL-H and Cp2ZrCl2 is shown to promote the regioselective cleavage of primary acetates on a broad scope of substrates, ranging from carbohydrates to terpene derivatives, with a high tolerance toward protecting groups and numerous functionalities found in natural products and bioactive compounds. Apart from providing highly valuable building blocks in only two steps from biosourced raw materials, this selective de-O-acetylation should also be strongly helpful to solve selectivity issues in organic synthesis.
https://hal-normandie-univ.archives-ouvertes.fr/hal-02197282
Contributor : Madeleine Roux-Merlin <>
Submitted on : Tuesday, July 30, 2019 - 11:31:09 AM
Last modification on : Thursday, July 2, 2020 - 3:29:20 AM
Contributor : Madeleine Roux-Merlin <>
Submitted on : Tuesday, July 30, 2019 - 11:31:09 AM
Last modification on : Thursday, July 2, 2020 - 3:29:20 AM
