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Article dans une revue
C5‐Disubstituted Meldrum’s Acid Derivatives as Platform for the Organocatalytic Synthesis of C3‐Alkylated Dihydrocoumarins
Abstract : C5‐disubstituted Meldrum's acid precursors were shown to be a useful platform for the synthesis of an array of 3‐alkylated dihydrocoumarins with up to 93:7 er, thanks to an enantioselective domino cyclization‐decarboxylative‐protonation reaction triggered by an unprecedented benzhydryl‐derived cupreine organocatalyst. This cyclization sequence was extended to an emerging organocatalytic decarboxylative‐chlorination reaction in the presence of trichloroquinolinone and by means of a bifunctional cinchona derived Brønsted base which gave rise to the formation of dihydrocoumarins (up to 79:21 er) with a tertiary chlorinated stereocenter.
https://hal-normandie-univ.archives-ouvertes.fr/hal-02197276
Contributeur : Madeleine Roux-Merlin <>
Soumis le : mardi 30 juillet 2019 - 11:26:30
Dernière modification le : mercredi 15 avril 2020 - 09:06:02
Contributeur : Madeleine Roux-Merlin <>
Soumis le : mardi 30 juillet 2019 - 11:26:30
Dernière modification le : mercredi 15 avril 2020 - 09:06:02
