Skip to Main content Skip to Navigation
Journal articles

Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers

Abstract : RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) have recently been involved in breast and ovarian cancer predisposition: RAD51B, RAD51C, and RAD51D in ovarian cancer, RAD51B and XRCC2 in breast cancer. The aim of this study was to estimate the contribution of deleterious variants in the five RAD51 paralogs to breast and ovarian cancers. The five RAD51 paralog genes were analyzed by next-generation sequencing technologies in germline DNA from 2649 consecutive patients diagnosed with breast and/or ovarian cancer. Twenty-one different deleterious variants were identified in the RAD51 paralogs in 30 patients: RAD51B (n = 4), RAD51C (n = 12), RAD51D (n = 7), XRCC2 (n = 2), and XRCC3 (n = 5). The overall deleterious variant rate was 1.13% (95% confidence interval (CI): 0.72–1.55%) (30/2649), including 15 variants in breast cancer only cases (15/2063; 0.73% (95% CI: 0.34–1.11%)) and 15 variants in cases with at least one ovarian cancer (15/570; 2.63% (95% CI: 1.24–4.02%)). This study is the first evaluation of the five RAD51 paralogs in breast and ovarian cancer predisposition and it demonstrates that deleterious variants can be present in breast cancer only cases. Moreover, this is the first time that XRCC3 deleterious variants have been identified in breast and ovarian cancer cases.
Document type :
Journal articles
Complete list of metadatas

https://hal-normandie-univ.archives-ouvertes.fr/hal-02194429
Contributor : Université Normandie <>
Submitted on : Thursday, July 25, 2019 - 2:58:39 PM
Last modification on : Tuesday, July 21, 2020 - 3:58:43 AM

Links full text

Identifiers

Citation

Lisa Golmard, Laurent Castéra, Sophie Krieger, Virginie Moncoutier, Khadija Abidallah, et al.. Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers. European Journal of Human Genetics, Nature Publishing Group, 2017, 25 (12), pp.1345-1353. ⟨10.1038/s41431-017-0021-2⟩. ⟨hal-02194429⟩

Share

Metrics

Record views

342