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Variant form of hairy cell leukemia

Margaux Wiber 1 Elsa Maitre 1, 2 Edouard Cornet 1, 2 Véronique Salaün 1 Dina Naguib 1 Xavier Troussard 1, 2
1 CHU Caen
2 GPMCND - Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques
Abstract : Mature lymphoid B-cell proliferations with hairy cells represent heterogeneous entities where specific diagnosis is difficult but important since it impacts therapeutic management. The clinical cases of variant hairy cell leukemia reported herein illustrate the persistence of a clear interest in the use of splenectomy as a therapeutic alternative. Furthermore, ibrutinib appears to be a promising treatment in patients with relapsed/refractory disease.
Keywords : BRAFV600E Ibrutinib KDM6A chronic B‐lymphoproliferative disorder hairy cell leukemia hairy cell leukemia variant
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Submitted on : Thursday, July 25, 2019 - 2:02:48 PM
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Margaux Wiber, Elsa Maitre, Edouard Cornet, Véronique Salaün, Dina Naguib, et al.. Variant form of hairy cell leukemia. Clinical Case Reports, Wiley, 2019, 7 (6), pp.1161-1166. ⟨10.1002/ccr3.2176⟩. ⟨hal-02194328⟩

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