Usefulness of thresholds for smear review of neutropenic samples analyzed with a Sysmex XN-10 analyzer

Abstract : Neutropenia is one of the main criteria for a blood smear review. The objective of this study was to compare the thresholds proposed by the international consensus group for hematology review (1.0 10/L) and the French speaking Group for Cellular Haematology (1.5 10/L) in terms of the number of useless smears. We collected 112,097 analyzed samples from four laboratories equipped with XN instruments (Sysmex, Kobe, Japan) during early 2016. The only exclusion criterion was a leucocyte count below 0.5 10/L. In the absence of abnormal cells and/or morphology suggesting haematological disease, samples were classified as 'negative for morphology' and the differential from the XN-10 was reported. These smear procedures were considered as uninformative. Some 2202 samples met the criterion for neutropenia (<1.5 10/L) for slide review representing 1.96% of the total. These included 1031 with neutropenia alone and 1171 neutropenia plus other abnormalities. Of the 1031 with neutropenia alone, 886 had a neutrophil count between 1.0 10/L and 1.5 10/L. The smear was uninformative for all of these samples. In conclusion, microscopic examination of a blood smear provided very limited information in cases of neutropenia without other abnormalities.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02194326
Contributeur : Université Normandie <>
Soumis le : jeudi 25 juillet 2019 - 13:56:09
Dernière modification le : lundi 29 juillet 2019 - 15:41:16

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Emily Ronez, Carole Geara, Sylvie Coito, Hugues Jacqmin, Edouard Cornet, et al.. Usefulness of thresholds for smear review of neutropenic samples analyzed with a Sysmex XN-10 analyzer. Scandinavian Journal of Clinical and Laboratory Investigation, 2017, 77 (6), pp.406-409. ⟨10.1080/00365513.2017.1334129⟩. ⟨hal-02194326⟩

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