Recommendations for cerebrospinal fluid examination in acute leukemia - Archive ouverte HAL Access content directly
Journal Articles Annales de Biologie Clinique Year : 2017

Recommendations for cerebrospinal fluid examination in acute leukemia

(1) , (2) , (1) , (3, 4) , (5)
1
2
3
4
5

Abstract

Cytological identification of blasts in cerebrospinal fluid in acute leukemia, lymphoid or myeloid, in adult and child, at diagnosis or during follow up lead to the diagnosis of leukemic meningitidis. Suitable CNS therapy based on a defined "CNS status" following an international standardized classification, lead to decrease cerebrospinal relapses. Established in 1993, this classification allows to treat patients based on their CNS status. Based on the red blood cells count, nucleated cells count and presence of blasts, it requires a standard technical procedure that guarantees the comparability of results coming from different medical laboratory. To improve the quality of cerebrospinal fluid analysis, in acute leukemias, preanalytical guidelines (turn around time), analytical guidelines (cytocentrifugation, adding serum protein, speed and duration of cytocentrifugation) and postanalytical guidelines (duration of conservation) are set by the Groupe francophone d'hématologie cellulaire.
Not file

Dates and versions

hal-02194322 , version 1 (25-07-2019)

Identifiers

Cite

Sandrine Girard, Odile Fenneteau, Fanélie Mestrallet, Xavier Troussard, Jean-François Lesesve. Recommendations for cerebrospinal fluid examination in acute leukemia. Annales de Biologie Clinique, 2017, 75 (5), pp.503-512. ⟨10.1684/abc.2017.1250⟩. ⟨hal-02194322⟩
61 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More