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Increased frequencies of circulating and tumor-resident Vδ1 T cells in patients with diffuse large B-cell lymphoma

Abstract : Gamma-delta (γδ) T cells contribute to the innate immune response against cancer. In samples of 20 patients upon DLBCL diagnosis, we found that Vδ1 T cells were the major γδ T cell subset in tumors and PBMCs of patients, while Vδ2 T cells were preponderant in PBMCs of healthy subjects. Interestingly, the germinal center (GC) subtype was associated with an increase in Vδ1 T cells in tumors, whereas the non-GC subtype was associated with a lower frequency of γδ T cells. While circulating Vδ1 T cells of patients or HSs mostly exhibited a naïve phenotype, the majority of tumor Vδ1 T cells showed a central memory phenotype. Resident or circulating γδ T cells from patients were not functionally impaired since they produced high levels of IFN-γ. Collectively, our findings are in favor of γδ T cell activation in tumors and open new perspectives for their modulation in DLBCL immunotherapy.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02194320
Contributor : Université Normandie <>
Submitted on : Thursday, July 25, 2019 - 1:55:57 PM
Last modification on : Wednesday, December 4, 2019 - 9:52:02 AM

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Emilie Reboursiere, Anne-Claire Gac, Anthony Garnier, Véronique Salaun, Oumedaly Reman, et al.. Increased frequencies of circulating and tumor-resident Vδ1 T cells in patients with diffuse large B-cell lymphoma. Leukemia and Lymphoma, 2018, 59 (1), pp.187-195. ⟨10.1080/10428194.2017.1321751⟩. ⟨hal-02194320⟩

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