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Journal articles
Increased frequencies of circulating and tumor-resident Vδ1 T cells in patients with diffuse large B-cell lymphoma
Emilie Reboursiere
1, 2
Anne-Claire Gac
1
Anthony Garnier
2
Véronique Salaun
1
Oumedaly Reman
1
Anne-Dominique Pham
1
Quentin Cabrera
1
Kathy Khoy
1
Jean-Pierre Vilque
1
Christophe Fruchart
1
Sylvain Chantepie
1
Hyacinthe Johnson-Ansah
1
Margaret Macro
1
Stéphane Cheze
1
Khaled Benabed
1
Jean-Baptiste Mear
1
Xavier Troussard
1, 3
Gandhi Damaj
1
Brigitte Le Mauff
1, 2
Olivier Toutirais
1, 2
Emilie Reboursiere 1, 2
Author
Anne-Claire Gac 1
Author
Anthony Garnier 2
Author
Véronique Salaun 1
Author
Jean-Pierre Vilque 1
Author
Christophe Fruchart 1
Author
Sylvain Chantepie 1
Author
Hyacinthe Johnson-Ansah 1
Author
Xavier Troussard 1, 3
Author
Gandhi Damaj 1
Author
Brigitte Le Mauff 1, 2
Author
Olivier Toutirais 1, 2
Author
1
CHU Caen (Avenue de la Côte de Nacre 14000 Caen - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- TCBN - Tumorothèque de Caen Basse-Normandie (3 avenue du Général Harris 14076 Caen cedex 5 - France)
2
Sérine protéases et physiopathologie de l'unité neurovasculaire (Campus Jules Horowitz - Boulevard Henri Becquerel - BP 5229 - 14074 CAEN Cedex 5. - France)
- UNICAEN - Université de Caen Normandie (Esplanade de la Paix - CS 14032 - 14032 CAEN Cedex 5 - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U919 (101, rue de Tolbiac, 75013 Paris - France)
3
GPMCND - Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (22, Boulevard Gambetta 76183 Rouen Cedex - France)
- UNIROUEN - Université de Rouen Normandie (1, rue Thomas Becket 76821 Mont-Saint-Aignan Cedex - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1245 (101, rue de Tolbiac, 75013 Paris - France)
Abstract : Gamma-delta (γδ) T cells contribute to the innate immune response against cancer. In samples of 20 patients upon DLBCL diagnosis, we found that Vδ1 T cells were the major γδ T cell subset in tumors and PBMCs of patients, while Vδ2 T cells were preponderant in PBMCs of healthy subjects. Interestingly, the germinal center (GC) subtype was associated with an increase in Vδ1 T cells in tumors, whereas the non-GC subtype was associated with a lower frequency of γδ T cells. While circulating Vδ1 T cells of patients or HSs mostly exhibited a naïve phenotype, the majority of tumor Vδ1 T cells showed a central memory phenotype. Resident or circulating γδ T cells from patients were not functionally impaired since they produced high levels of IFN-γ. Collectively, our findings are in favor of γδ T cell activation in tumors and open new perspectives for their modulation in DLBCL immunotherapy.
Document type :
Journal articles
Domain :
Complete list of metadatas
https://hal-normandie-univ.archives-ouvertes.fr/hal-02194320
Contributor : Université Normandie <>
Submitted on : Thursday, July 25, 2019 - 1:55:57 PM
Last modification on : Wednesday, December 4, 2019 - 9:52:02 AM
Contributor : Université Normandie <>
Submitted on : Thursday, July 25, 2019 - 1:55:57 PM
Last modification on : Wednesday, December 4, 2019 - 9:52:02 AM
Identifiers
- HAL Id : hal-02194320, version 1
- DOI : 10.1080/10428194.2017.1321751
- PUBMED : 28562153
Collections
COMUE-NORMANDIE | GPMCND-MICAH | UNIROUEN | UNICAEN | GPMCND
Citation
Emilie Reboursiere, Anne-Claire Gac, Anthony Garnier, Véronique Salaun, Oumedaly Reman, et al.. Increased frequencies of circulating and tumor-resident Vδ1 T cells in patients with diffuse large B-cell lymphoma. Leukemia and Lymphoma, 2018, 59 (1), pp.187-195. ⟨10.1080/10428194.2017.1321751⟩. ⟨hal-02194320⟩
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