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Trabecular Bone Score: Where are we now?

Valérie Bousson 1 Catherine Bergot 2 Bruno Sutter 3, 4 Thierry Thomas 5 Sauveur Bendavid Claude-Laurent Benhamou 6 Hubert Blain 7 Michel Brazier 8 Véronique Breuil 9 Karine Briot 10, 11, 12 Roland D. Chapurlat 13 Laure Chapuis 14 Martine Cohen Solal 1, 15 Patrice Fardellone 16 Jean-Marc Feron 17 Jean-Bernard Gauvain 18 Michel Laroche 19 Erick Legrand 20 Eric Lespessailles 21 Agnès Linglart 22 Christian Marcelli 23, 24 Christian Roux 11, 10, 12 Jean-Claude Souberbielle 25 Florence Trémollières 26 Georges Weryha 27 Bernard Cortet 28 
Abstract : The Trabecular Bone Score is a rather new index obtained at the lumbar spine at the same time as a real bone mineral density. It was developed to reflect bone microarchitecture. It was proposed to be easily used in everyday practice as a surrogate of bone strength. Our aim was to review 1. technical points such as correlations between Trabecular Bone Score and bone microarchitectural parameters, Trabecular Bone Score and bone strength, the effects of dual-energy X-ray absorptiometry image spatial resolution, age, macroarchitecture, body mass index, and osteoarthritis, on Trabecular Bone Score, and 2. evidences to use Trabecular Bone Score for separating individuals with fragility fractures from controls, predicting fragility fractures, and for longitudinally monitoring changes related to treatments. Correlations between Trabecular Bone Score and bone microarchitectural parameters vary widely across bone sites, microarchitectural parameters, and study designs. In vivo, the Trabecular Bone Score explains little of the variance in trabecular microarchitectural parameters. We emphasize that it is a texture parameter. The Trabecular Bone Score is reduced in patients with fragility fracture. Several retrospective and prospective studies have shown its discriminative ability regarding the fracture risk. When combining the areal Bone mineral Density and Trabecular Bone Score, the Trabecular Bone Score remains a predictor of fracture but not the areal Bone Mineral Density. However in prospective studies, the best predictor of fracture remains hip areal bone mineral density. Due to the lack of evidence, we recommend not to use Trabecular Bone Score for following patients treated by anti-osteoporotic drugs.
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Submitted on : Monday, July 22, 2019 - 2:38:55 PM
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Valérie Bousson, Catherine Bergot, Bruno Sutter, Thierry Thomas, Sauveur Bendavid, et al.. Trabecular Bone Score: Where are we now?. Joint Bone Spine, 2015, 82 (5), pp.320-325. ⟨10.1016/j.jbspin.2015.02.005⟩. ⟨hal-02190441⟩



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