The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A(2A) adenosine receptor antagonists

M El Yacoubi (1) , C Ledent (2) , M Parmentier (2) , J Costentin (1) , J. M. Vaugeois (1)

1 Unité de neuropsychopharmacologie expérimentale
2 ULB - Université libre de Bruxelles

The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs.

Domaines: Médecine humaine et pathologie

M El Yacoubi, C Ledent, M Parmentier, J Costentin, J. M. Vaugeois. The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A(2A) adenosine receptor antagonists. Psychopharmacology, 2000, 148 (2), pp.153-63. ⟨10.1007/s002130050037⟩. ⟨hal-02186999⟩