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Pharmacological modifications of dopamine transmission do not influence the striatal in vivo binding of [3H]mazindol or [3H]cocaine in mice

Abstract : We have considered the in vivo striatal binding of two ligands of the neuronal dopamine uptake complex [3H]cocaine and [3H]mazindol. The [3H]cocaine tracer dose labelled the dopamine uptake complex in striatum but not the noradrenaline complex in cerebellum. On the contrary, the [3H]mazindol tracer dose induced a marked labelling of the noradrenaline uptake complex in cerebellum; its prevention by desipramine (5 mg/kg) increased simultaneously the cerebral bioavailability and thereby the striatal labelling of the dopamine transporter. In mice submitted to treatments modifying dopaminergic transmission either to decrease it (gammabutyrolactone, 750 mg/kg, i.p.) or to increase it (L-DOPA, 200 mg/kg, i.p., dexamphetamine, 4 mg/kg, s.c., or their combination), only dexamphetamine pretreatment significantly reduced [3H]cocaine and [3H]mazindol binding. Thus it appears that the level of dopamine transmission would not interfere with the in vivo quantification of striatal dopamine uptake sites assessed with either ligands.
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Submitted on : Wednesday, July 17, 2019 - 3:29:59 PM
Last modification on : Tuesday, October 19, 2021 - 4:18:10 PM

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F Thibaut, J J Bonnet, J. M. Vaugeois, J Costentin. Pharmacological modifications of dopamine transmission do not influence the striatal in vivo binding of [3H]mazindol or [3H]cocaine in mice. Neuroscience Letters, Elsevier, 1996, 205 (3), pp.145-8. ⟨10.1016/0304-3940(96)12399-5⟩. ⟨hal-02186987⟩

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