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The H/Rouen mouse model displays depression-like and anxiety-like behaviors

Abstract : Cardinal symptoms of depression include helplessness and anhedonia. In addition, depression and anxiety are often comorbid disorders. H/Rouen mice, a genetic mouse model of depression, display helpless behavior in the tail suspension test, whereas non-helpless NH/Rouen mice show the opposite behavior. It is unknown whether H/Rouen mice display an anxious behavior as compared to NH/Rouen mice, and is unclear whether they display anhedonia. Time spent in the periphery of an open-field, an index of anxiety, was found to be higher in male and female H/Rouen mice as compared to NH/Rouen mice. In the elevated plus-maze, a decrease in the number of entries and in the time spent in the open arms was observed in both male and female H/Rouen. In the light/dark box, the number of entries and the time spent in the anxiogenic bright compartment was significantly reduced in male and female H/Rouen mice. In addition, the preference of consumption of a 2% sucrose solution was significantly reduced in male and female H/Rouen mice as compared to NH/Rouen and I/Rouen mice in a two-bottle choice paradigm but was restored by a chronic (3 weeks) fluoxetine treatment. H/Rouen mice thus display both anxiety and anhedonia making them a potent animal model in the treatment of forms depression comorbidly expressed with anxiety.
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https://hal-normandie-univ.archives-ouvertes.fr/hal-02185497
Contributor : Université Normandie <>
Submitted on : Tuesday, July 16, 2019 - 4:22:15 PM
Last modification on : Monday, February 24, 2020 - 2:24:15 PM

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Malika El Yacoubi, Virginie Rappeneau, Eddy Champion, Gaël Malleret, Jean-Marie Vaugeois. The H/Rouen mouse model displays depression-like and anxiety-like behaviors. Behavioural Brain Research, Elsevier, 2013, 256, pp.43-50. ⟨10.1016/j.bbr.2013.07.048⟩. ⟨hal-02185497⟩

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